A Literature Review and Meta-Analysis on the Potential Use of miR-150 as a Novel Biomarker in the Detection and Progression of Multiple Sclerosis.

Autor:	Arcas VC; Doctoral School, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania., Fratila AM; Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.; Military Clinical Emergency Hospital of Sibiu, 550024 Sibiu, Romania., Moga DFC; Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.; Military Clinical Emergency Hospital of Sibiu, 550024 Sibiu, Romania., Roman-Filip I; Department of Neurology, 'George Emil Palade' University of Medicine, Pharmacy, Sciences and Technology, 540136 Targu Mures, Romania., Arcas AC; Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy of Cluj-Napoca, 400012 Cluj-Napoca, Romania., Roman-Filip C; Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.; Emergency County Clinical Hospital Sibiu, 550245 Sibiu, Romania., Sava M; Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.; Emergency County Clinical Hospital Sibiu, 550245 Sibiu, Romania.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2024 Jul 31; Vol. 14 (8). Date of Electronic Publication: 2024 Jul 31.
DOI:	10.3390/jpm14080815
Abstrakt:	Background: MicroRNA-150 (miR-150) plays a critical role in immune regulation and has been implicated in autoimmune diseases like Multiple Sclerosis (MS). This review aims to evaluate miR-150's potential as a biomarker for MS, necessitating this review to consolidate current evidence and highlight miR-150's utility in improving diagnostic accuracy and monitoring disease progression. Methods: A comprehensive literature search was conducted in databases like PubMed, Scopus, Google Scholar, SciSpace, MDPI and Web of Science, adhering to PRISMA guidelines. Studies focusing on miR-150 implications in MS were included. Data extraction was conducted, while quality assessment was done using the NOS and AMSTAR 2 tools. With the extracted data a statistical analyses conducted. Results: 10 eligible articles were included in review. Findings show that miR-150 levels were consistently deregulated in MS patients compared to healthy controls, correlating with disease severity and clinical parameters such as (EDSS) scores and disease activity. Additionally, miR-150 is implicated in the inflammatory pathogenesis of MS, affecting immune cell regulation and inflammatory pathways. Conclusions: MiR-150 is a promising biomarker for MS, showing significant potential for improving diagnostic accuracy and monitoring disease progression. Its consistent deregulation in MS patients and correlation with clinical parameters underscore its clinical utility. Further research should validate miR-150's salivary presence and its possible usage as a novel biomarker and therapeutic potential in the development of MS.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu