Radiosurgery in Grade II and III Meningiomas: A Systematic Review and Meta-Analysis.

Autor:	Jahanbakhshi A; Skull Base Research Center, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran 1997667665, Iran., Najafi M; Skull Base Research Center, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran 1997667665, Iran., Gomar M; Radiation Oncology Research Center, Iran Cancer Institute, Tehran University of Medical Sciences, Tehran 1997667665, Iran., Ciammella P; Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy., Ruggieri MP; Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy., Iotti C; Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy., Finocchi Ghersi S; Radiation Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy., Serre AA; Radiation Oncology Department, Centre Leon Berard, 69373 Lyon, France., Bardoscia L; Radiation Oncology Unit, S. Luca Hospital, Healthcare Company Tuscany Nord Ovest, 55100 Lucca, Italy., Sardaro A; Interdisciplinary Department of Medicine, Section of Radiology and Radiation Oncology, University of Bari 'Aldo Moro', 70124 Bari, Italy., Boisbouvier S; Radiation Oncology Department, Centre Leon Berard, 69373 Lyon, France., Roukoz C; Radiation Oncology Department, Centre Leon Berard, 69373 Lyon, France., Cozzi S; Radiation Oncology Department, Centre Leon Berard, 69373 Lyon, France.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2024 Jul 29; Vol. 14 (8). Date of Electronic Publication: 2024 Jul 29.
DOI:	10.3390/jpm14080802
Abstrakt:	Background: Meningiomas are the most prevalent benign intracranial tumors. When they are of the invasive subtypes, i.e., grades II and III, they can recur rapidly and present a real challenge for physicians. This study is focused on the use of stereotactic radiosurgery to manage high-grade meningiomas. Method: Medline via PubMed was searched from inception to December 2022 to retrieve studies on stereotactic radiation therapy for patients with grade II-III meningiomas. This study was conducted under PRISMA guidelines. Result: A total of 29 articles involving 1446 patients with grade II-III meningiomas treated with stereotactic radiation therapy were included in the present study. Of these studies, 11 were conducted exclusively on patients with atypical meningiomas (grade II), 1 targeted anaplastic meningiomas (grade III), and 17 articles were carried out on both grade II and III meningiomas. The pooled 1, 2, 3, 5, and 10-year overall survival (OS) of grade II meningiomas was 0.96 [ p < 0.01], 0.89 [ p = 0.01], 0.90 [ p = 0.09], 0.81 [ p < 0.01], and 0.66 [ p = 0.55], respectively. The pooled 2, 5, and 10-year OS of grade III meningiomas was 0.64 [ p = 0.01], 0.41 [ p = 0.01], and 0.19 [ p < 0.01], respectively. Conclusions: Although long-term prospective studies are still required, the outcomes of stereotactic radiation therapy appear promising regarding overall outcome and progression-free survival.
Databáze:	MEDLINE
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