| Autor: |
Kim JH; Department of Pharmacology, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Seok JY; Department of Pharmacology, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Kim YH; Department of Biology Education, Institute of Agriculture and Life Science (IALS), Gyeongsang National University, Jinju 52609, Republic of Korea., Kim HJ; Department of Physiology, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Lee JK; Department of Pharmacology, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea., Kim HR; Department of Pharmacology, College of Medicine, Dankook University, Cheonan 31116, Republic of Korea. |
| Abstrakt: |
The widespread use of wireless communication devices has necessitated unavoidable exposure to radiofrequency electromagnetic fields (RF-EMF). In particular, increasing RF-EMF exposure among children is primarily driven by mobile phone use. Therefore, this study investigated the effects of 1850 MHz RF-EMF exposure at a specific absorption rate of 4.0 W/kg on cortical neurons in mice at postnatal day 28. The results indicated a significant reduction in the number of mushroom-shaped dendritic spines in the prefrontal cortex after daily exposure for 4 weeks. Additionally, prolonged RF-EMF exposure over 9 days led to a gradual decrease in postsynaptic density 95 puncta and inhibited neurite outgrowth in developing cortical neurons. Moreover, the expression levels of genes associated with synapse formation, such as synaptic cell adhesion molecules and cyclin-dependent kinase 5, were reduced in the cerebral cortexes of RF-EMF-exposed mice. Behavioral assessments using the Morris water maze revealed altered spatial learning and memory after the 4-week exposure period. These findings underscore the potential of RF-EMF exposure during childhood to disrupt synaptic function in the cerebral cortex, thereby affecting the developmental stages of the nervous system and potentially influencing later cognitive function. |
