Long-Term Functional Outcomes Following Enzymatic Debridement of Deep Hand Burns Using Nexobrid ® : A Retrospective Analysis.

Autor: Malsagova AT; Department for Plastic, Reconstructive and Hand Surgery, Burn Center for Severe Burn Injuries, Nuremberg Hospital, Paracelsus Medical University, Breslauer Str. 201, 90471 Nuremberg/Prof.-Ernst-Nathan Straße 1, 90419 Nuremberg, Germany., El-Habbassi A; Paracelsus Medical University Salzburg, Muellner Hauptstr. 48, 5020 Salzburg, Austria., Billner M; Department for Plastic, Reconstructive and Hand Surgery, Burn Center for Severe Burn Injuries, Nuremberg Hospital, Paracelsus Medical University, Breslauer Str. 201, 90471 Nuremberg/Prof.-Ernst-Nathan Straße 1, 90419 Nuremberg, Germany., Berns M; Department for Plastic, Reconstructive and Hand Surgery, Burn Center for Severe Burn Injuries, Nuremberg Hospital, Paracelsus Medical University, Breslauer Str. 201, 90471 Nuremberg/Prof.-Ernst-Nathan Straße 1, 90419 Nuremberg, Germany., Pueski T; Department for Plastic, Reconstructive and Hand Surgery, Burn Center for Severe Burn Injuries, Nuremberg Hospital, Paracelsus Medical University, Breslauer Str. 201, 90471 Nuremberg/Prof.-Ernst-Nathan Straße 1, 90419 Nuremberg, Germany., Bodenschatz KJ; Department for Pediatric Surgery, Nuremberg Hospital, Paracelsus Medical University, Breslauer Str. 201, 90471 Nuremberg/Prof.-Ernst-Nathan Straße 1, 90419 Nuremberg, Germany., Heidekrueger PI; Centre of Plastic, Aesthetic, Hand and Reconstructive Surgery, University of Regensburg, Universitätsstraße 31, 93053 Regensburg, Germany., Ehrl D; Department for Plastic, Reconstructive and Hand Surgery, Burn Center for Severe Burn Injuries, Nuremberg Hospital, Paracelsus Medical University, Breslauer Str. 201, 90471 Nuremberg/Prof.-Ernst-Nathan Straße 1, 90419 Nuremberg, Germany.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Aug 12; Vol. 13 (16). Date of Electronic Publication: 2024 Aug 12.
DOI: 10.3390/jcm13164729
Abstrakt: Background : For years, surgical debridement with autografting has been considered the standard of care in the treatment of severe burns of the hand. However, in recent years, enzymatic debridement has increasingly been reported as a good alternative, especially for burns of the hand, as it selectively preserves viable tissue. In this study, we aim to evaluate the long-term function of the hand after enzymatic debridement in deep dermal burns. Methods : A retrospective chart review was conducted as well as measurements of subjective and objective outcome measures through physical examination and Disabilities of the Arm, Shoulder, and Hand (DASH), Patient and Observer Scar Assessment Scale (POSAS), and Vancouver Scar Scale (VSS) scores. Results : A total of 32 enzymatically debrided hands of 24 patients were included with a mean age of 42.4 ± 16.8 years and a mean follow-up of 31 months. Postoperatively, 19 of these could be managed conservatively using skin substitutes such as "Suprathel", 13 had to undergo subsequent autografting. The mean DASH score for the entire study population was eight with a mean value of four in the conservatively managed group and fourteen in the autografted group. The mean Patient, Observer POSAS, and VSS values were nineteen, thirteen, and two. A total of 30 cases showed an effortless complete fist closure, and, also in 30 cases, patients attested to be satisfied with the esthetic appearance of the hand on being asked. Conclusions : The descriptive analysis of these results in our study population suggests that the enzymatic debridement of deep burns of the hand, especially combined with subsequent conservative management with skin substitutes, was associated with low long-term hand disability scores at a follow-up of two years.
Databáze: MEDLINE
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