Guided Plasma Application in Dentistry-An Alternative to Antibiotic Therapy.

Autor:	Gross T; Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.; Center for Tissue Replacement, Regeneration & Neogenesis (GERN), Department of Operative Dentistry and Periodontology, Medical Center, Faculty of Medicine, University of Freiburg, 79108 Freiburg, Germany., Ledernez LA; Laboratory for Sensors, Department of Microsystems Engineering (IMTEK), University of Freiburg, 79110 Freiburg, Germany., Birrer L; Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.; Center for Tissue Replacement, Regeneration & Neogenesis (GERN), Department of Operative Dentistry and Periodontology, Medical Center, Faculty of Medicine, University of Freiburg, 79108 Freiburg, Germany.; Laboratory for Sensors, Department of Microsystems Engineering (IMTEK), University of Freiburg, 79110 Freiburg, Germany., Bergmann ME; Laboratory for Sensors, Department of Microsystems Engineering (IMTEK), University of Freiburg, 79110 Freiburg, Germany., Altenburger MJ; Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.; Center for Tissue Replacement, Regeneration & Neogenesis (GERN), Department of Operative Dentistry and Periodontology, Medical Center, Faculty of Medicine, University of Freiburg, 79108 Freiburg, Germany.
Jazyk:	angličtina
Zdroj:	Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2024 Aug 05; Vol. 13 (8). Date of Electronic Publication: 2024 Aug 05.
DOI:	10.3390/antibiotics13080735
Abstrakt:	Cold atmospheric plasma (CAP) is a promising alternative to antibiotics and chemical substances in dentistry that can reduce the risk of unwanted side effects and bacterial resistance. AmbiJet is a device that can ignite and deliver plasma directly to the site of action for maximum effectiveness. The aim of the study was to investigate its antimicrobial efficacy and the possible development of bacterial resistance. The antimicrobial effect of the plasma was tested under aerobic and anaerobic conditions on bacteria (five aerobic, three anaerobic (Gram +/-)) that are relevant in dentistry. The application times varied from 1 to 7 min. Possible bacterial resistance was evaluated by repeated plasma applications (10 times in 50 days). A possible increase in temperature was measured. Plasma effectively killed 10 6 seeded aerobic and anaerobic bacteria after an application time of 1 min per 10 mm 2 . Neither the development of resistance nor an increase in temperature above 40 °C was observed, so patient discomfort can be ruled out. The plasma treatment proved to be effective under anaerobic conditions, so the influence of ROS can be questioned. Our results show that AmbiJet efficiently eliminates pathogenic oral bacteria. Therefore, it can be advocated for clinical therapeutic use.
Databáze:	MEDLINE
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