| Autor: |
Kehl A; Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany.; Comparative Experimental Pathology, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany., Kuder H; Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany., Parkinson L; College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA., Koenig A; College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA., Langbein-Detsch I; Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany., Mueller E; Laboklin GmbH & Co. KG, 97688 Bad Kissingen, Germany., Giger U; Vetsuisse Faculty, Klinik für Kleintiermedizin, University of Zürich, 8057 Zürich, Switzerland. |
| Jazyk: |
angličtina |
| Zdroj: |
Animals : an open access journal from MDPI [Animals (Basel)] 2024 Aug 22; Vol. 14 (16). Date of Electronic Publication: 2024 Aug 22. |
| DOI: |
10.3390/ani14162442 |
| Abstrakt: |
Different blood group systems have been characterized in people and other mammals. In domestic cats, the ABC blood group system plays the most important clinical role and has been investigated extensively-from the phenotype to the molecular genetics. In non-domestic felids, phenotypic ABC blood typing has been performed by different methods to detect the antigens, but the four informative CMAH markers in domestic cats were not able to identify types B and C ( AB ) in non-domestic cats. In this study, 138 blood samples from 15 non-domestic (wild) felid species were investigated by CMAH exonic sequencing and genotyping for putative variants causing type B or C ( AB ) and correlation to the respective ABC blood phenotype. A total of 58 CMAH variants were found, including 15 missense and 43 synonymous CMAH variants. One variant (c.635G>C) was concordant with blood type B (and C ) in cheetahs and type B in cougars, compared to blood type A in all other felid species (lion, tiger, Canada lynx, snow leopard, clouded leopard, serval, jaguar, fishing cat, Pallas cat, bobcat, black footed cat, leopard, and sand cat). Since cheetahs and cougars belong to the genera puma, it could not be determined if the common CMAH variant is either a marker for type B (or C ) or is just common in pumas. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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