| Autor: |
Navegantes Lima KC; Neuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Pará, Pará 66075-110, Brazil., Gaspar SLF; School of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil., Oliveira ALB; Neuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Pará, Pará 66075-110, Brazil., Santos SMD; Pharmaceutical Science Post-Graduation Program, Faculty of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil., Quadros LBG; School of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil., Oliveira JP; School of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil., Pereira RCDS; School of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil., Dias AGDS; School of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil., Gato LDS; School of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil., Alencar LYN; Medical School, Medical Science Institute, Federal University of Pará, Belém 66075-110, Brazil., Dos Santos ALP; School of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil., Dorneles GP; Laboratory of Cellular and Molecular Immunology, Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, Brazil., Romão PRT; Laboratory of Cellular and Molecular Immunology, Department of Basic Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre 90050-170, Brazil., Stutz H; Department of Food Engineering, Midwest State University-UNICENTRO, Simeao de Camargo Varela de Sá, 03, Guarapuava 85.040-080, Brazil., Sovrani V; Department of Food Engineering, Midwest State University-UNICENTRO, Simeao de Camargo Varela de Sá, 03, Guarapuava 85.040-080, Brazil., Monteiro MC; Neuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Pará, Pará 66075-110, Brazil.; School of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.; Pharmaceutical Science Post-Graduation Program, Faculty of Pharmacy, Federal University of Pará, Belém 66075-110, Brazil. |
| Abstrakt: |
Sepsis is a potentially fatal clinical condition that results from an immune imbalance in the host during an infection. It presents systemic alterations due to excessive activation of pro-inflammatory mediators that contribute to inflammation, formation of reactive species, and tissue damage. Anti-inflammatory mediators are then extensively activated to regulate this process, leading to immune exhaustion and, consequently, immunosuppression of the host. Considering the biological activities of the nutraceutical Agaricus brasiliensis ( A. brasiliensis ), such as immunomodulatory, antioxidant, and antitumor activities, the present study investigated the therapeutic potential of the lipid fraction of A. brasiliensis (LF) in a model of lethal sepsis in mice ( Mus musculus ), induced by cecal ligation and perforation (CLP). The results showed that treatment of septic animals with LF or LF associated with ertapenem (LF-Erta) reduced systemic inflammation, promoting improvement in clinical parameters and increased survival. The data show a reduction in pro-inflammatory and oxidative stress markers, regulation of the anti-inflammatory response and oxidizing agents, and increased bacterial clearance in the peritoneal cavity and liver. Thus, it can be concluded that LF as a treatment, and in conjunction with antibiotic therapy, has shown promising effects as a hepatoprotective, antioxidant, antimicrobial, and immunomodulatory agent. |
