| Autor: |
Ilie CI; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.; National Centre for Micro and Nanomaterials and National Centre for Food Safety, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania., Spoiala A; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.; National Centre for Micro and Nanomaterials and National Centre for Food Safety, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania.; Research Center for Advanced Materials, Products and Processes, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania., Chircov C; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.; National Centre for Micro and Nanomaterials and National Centre for Food Safety, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania., Dolete G; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.; National Centre for Micro and Nanomaterials and National Centre for Food Safety, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania.; Research Center for Advanced Materials, Products and Processes, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania., Oprea OC; Academy of Romanian Scientists, 010719 Bucharest, Romania.; Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania., Vasile BS; National Centre for Micro and Nanomaterials and National Centre for Food Safety, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania.; Research Center for Advanced Materials, Products and Processes, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania.; Academy of Romanian Scientists, 010719 Bucharest, Romania., Crainiceanu SA; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania., Nicoara AI; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.; National Centre for Micro and Nanomaterials and National Centre for Food Safety, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania., Marinas IC; The Research Institute, University of Bucharest, 050663 Bucharest, Romania., Stan MS; The Research Institute, University of Bucharest, 050663 Bucharest, Romania.; Department of Biochemistry, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania., Ditu LM; The Research Institute, University of Bucharest, 050663 Bucharest, Romania.; Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, 060101 Bucharest, Romania., Ficai A; Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.; National Centre for Micro and Nanomaterials and National Centre for Food Safety, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania.; Academy of Romanian Scientists, 010719 Bucharest, Romania., Oprea E; Department of Botany and Microbiology, Faculty of Biology, University of Bucharest, 060101 Bucharest, Romania. |
| Abstrakt: |
The gut microbiota dysbiosis that often occurs in cancer therapy requires more efficient treatment options to be developed. In this concern, the present research approach is to develop drug delivery systems based on magnetite nanoparticles (MNPs) as nanocarriers for bioactive compounds. First, MNPs were synthesized through the spraying-assisted coprecipitation method, followed by loading bee pollen or bee bread extracts and an antitumoral drug (5-fluorouracil/5-FU). The loaded-MNPs were morphologically and structurally characterized through transmission electron microscopy (TEM), selected area electron diffraction (SAED), scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Dynamic Light Scattering (DLS), and thermogravimetric analysis. UV-Vis spectroscopy was applied to establish the release profiles and antioxidant activity. Furthermore, the antibacterial and antitumoral activity of loaded-MNPs was assessed. The results demonstrate that MNPs with antioxidant, antibacterial, antiproliferative, and prebiotic properties are obtained. Moreover, the data highlight the improvement of 5-FU antibacterial activity by loading on the MNPs' surface and the synergistic effects between the anticancer drug and phenolic compounds (PCs). In addition, the prolonged release behavior of PCs for many hours (70-75 h) after the release of 5-FU from the developed nanocarriers is an advantage, at least from the point of view of the antioxidant activity of PCs. Considering the enhancement of L. rhamnosus MF9 growth and antitumoral activity, this study developed promising drug delivery alternatives for colorectal cancer therapy. |
