Amino acid metabolism in kidney health and disease.

Autor: Knol MGE; Department of Biomedicine, Aarhus University, Aarhus, Denmark.; Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Wulfmeyer VC; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Müller RU; Department II of Internal Medicine and Center for Molecular Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany., Rinschen MM; Department of Biomedicine, Aarhus University, Aarhus, Denmark. rinschen@biomed.au.dk.; III Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany. rinschen@biomed.au.dk.; Aarhus Institute of Advanced Studies, Aarhus University, Aarhus, Denmark. rinschen@biomed.au.dk.; Hamburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. rinschen@biomed.au.dk.
Jazyk: angličtina
Zdroj: Nature reviews. Nephrology [Nat Rev Nephrol] 2024 Dec; Vol. 20 (12), pp. 771-788. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1038/s41581-024-00872-8
Abstrakt: Amino acids form peptides and proteins and are therefore considered the main building blocks of life. The kidney has an important but under-appreciated role in the synthesis, degradation, filtration, reabsorption and excretion of amino acids, acting to retain useful metabolites while excreting potentially harmful and waste products from amino acid metabolism. A complex network of kidney transporters and enzymes guides these processes and moderates the competing concentrations of various metabolites and amino acid products. Kidney amino acid metabolism contributes to gluconeogenesis, nitrogen clearance, acid-base metabolism and provision of fuel for tricarboxylic acid cycle and urea cycle intermediates, and is thus a central hub for homeostasis. Conversely, kidney disease affects the levels and metabolism of a variety of amino acids. Here, we review the metabolic role of the kidney in amino acid metabolism and describe how different diseases of the kidney lead to aberrations in amino acid metabolism. Improved understanding of the metabolic and communication routes that are affected by disease could provide new mechanistic insights into the pathogenesis of kidney diseases and potentially enable targeted dietary or pharmacological interventions.
Competing Interests: Competing interests R.U.M. is a member of the scientific advisory board of Santa Barbara Nutrients and chair of the working group Genes&Kidney of the European Renal Association. M.M.R. reports research funding from Novo Nordisk A/S. The other authors declare no competing interests.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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