Activity of nested neural circuits drives different courtship songs in Drosophila.

Autor: Shiozaki HM; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. shiozaki.h@gmail.com., Wang K; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; Lingang Laboratory, Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai, China., Lillvis JL; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Xu M; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA., Dickson BJ; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.; Queensland Brain Institute, University of Queensland, St Lucia, Queensland, Australia., Stern DL; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA. sternd@janelia.hhmi.org.
Jazyk: angličtina
Zdroj: Nature neuroscience [Nat Neurosci] 2024 Oct; Vol. 27 (10), pp. 1954-1965. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1038/s41593-024-01738-9
Abstrakt: Motor systems implement diverse motor programs to pattern behavioral sequences, yet how different motor actions are controlled on a moment-by-moment basis remains unclear. Here, we investigated the neural circuit mechanisms underlying the control of distinct courtship songs in Drosophila. Courting males rapidly alternate between two types of song: pulse and sine. By recording calcium signals in the ventral nerve cord in singing flies, we found that one neural population is active during both songs, whereas an expanded neural population, which includes neurons from the first population, is active during pulse song. Brain recordings showed that this nested activation pattern is present in two descending pathways required for singing. Connectomic analysis reveals that these two descending pathways provide structured input to ventral nerve cord neurons in a manner consistent with their activation patterns. These results suggest that nested premotor circuit activity, directed by distinct descending signals, enables rapid switching between motor actions.
(© 2024. The Author(s).)
Databáze: MEDLINE
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