Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children.

Autor:	Zhao S; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Semeia L; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Veit R; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany., Luo S; Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Department of Psychology, University of Southern California, Los Angeles, CA, USA.; Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Angelo BC; Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Chow T; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA., Birkenfeld AL; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany.; Department of Internal Medicine, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls University Tübingen, Tübingen, Germany., Preissl H; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.; German Center for Diabetes Research (DZD), Tübingen, Germany.; Department of Internal Medicine, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls University Tübingen, Tübingen, Germany.; Department of Pharmacy and Biochemistry, Eberhard Karls University Tübingen, Tübingen, Germany., Xiang AH; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA., Page KA; Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Diabetes and Obesity Research Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA., Kullmann S; Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany. Stephanie.Kullmann@med.uni-tuebingen.de.; German Center for Diabetes Research (DZD), Tübingen, Germany. Stephanie.Kullmann@med.uni-tuebingen.de.; Department of Internal Medicine, Division of Diabetology, Endocrinology and Nephrology, Eberhard Karls University Tübingen, Tübingen, Germany. Stephanie.Kullmann@med.uni-tuebingen.de.
Jazyk:	angličtina
Zdroj:	International journal of obesity (2005) [Int J Obes (Lond)] 2024 Dec; Vol. 48 (12), pp. 1728-1734. Date of Electronic Publication: 2024 Aug 28.
DOI:	10.1038/s41366-024-01608-1
Abstrakt:	Objectives: Intrauterine exposure to gestational diabetes mellitus (GDM) increases the risk of obesity in the offspring, but little is known about the underlying neural mechanisms. The hippocampus is crucial for food intake regulation and is vulnerable to the effects of obesity. The purpose of the study was to investigate whether GDM exposure affects hippocampal functional connectivity during exposure to food cues using functional magnetic resonance imaging (fMRI). Methods: Participants were 90 children age 7-11 years (53 females) who underwent an fMRI-based visual food cue task in the fasted state. Hippocampal functional connectivity (FC) was examined using generalized psychophysiological interaction in response to food versus non-food cues. Hippocampal FC was compared between children with and without GDM exposure, while controlling for possible confounding effects of age, sex and waist-to-hip ratio. In addition, the influence of childhood and maternal obesity were investigated using multiple regression models. Results: While viewing high caloric food cues compared to non-food cure, children with GDM exposure exhibited higher hippocampal FC to the insula and striatum (i.e., putamen, pallidum and nucleus accumbens) compared to unexposed children. With increasing BMI, children with GDM exposure had lower hippocampal FC to the somatosensory cortex (i.e., postcentral gyrus). Conclusions: Intrauterine exposure to GDM was associated with higher food-cue induced hippocampal FC especially to reward processing regions. Future studies with longitudinal measurements are needed to clarify whether altered hippocampal FC may raise the risk of the development of metabolic diseases later in life. Competing Interests: Competing interests: The authors declare no competing interests. (© 2024. The Author(s).)
Databáze:	MEDLINE
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