Natural products: A potential immunomodulators against inflammatory-related diseases.

Autor: Sai Priya T; Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Ramalingam V; Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Suresh Babu K; Department of Natural Products & Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. suresh@iict.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. suresh@iict.res.in.
Jazyk: angličtina
Zdroj: Inflammopharmacology [Inflammopharmacology] 2024 Oct; Vol. 32 (5), pp. 2821-2859. Date of Electronic Publication: 2024 Aug 28.
DOI: 10.1007/s10787-024-01562-4
Abstrakt: The incidence and prevalence of inflammatory-related diseases (IRDs) are increasing worldwide. Current approved treatments for IRDs in the clinic are combat against inhibiting the pro-inflammatory cytokines. Though significant development in the treatment in the IRDs has been achieved, the severe side effects and inefficiency of currently practicing treatments are endless challenge. Drug discovery from natural sources is efficacious over a resurgence and also natural products are leading than the synthetic molecules in both clinical trials and market. The use of natural products against IRDs is a conventional therapeutic approach since it is a reservoir of unique structural chemistry, accessibility and bioactivities with reduced side effects and low toxicity. In this review, we discuss the cause of IRDs, treatment of options for IRDs and the impact and adverse effects of currently practicing clinical drugs. As well, the significant role of natural products against various IRDs, the limitations in the clinical development of natural products and thus pave the way for development of natural products as immunomodulators against IRDs are also discussed.
(© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
Externí odkaz: