Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion.

Autor: Tuz AA; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Ghosh S; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany., Karsch L; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Ttoouli D; Bioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany., Sata SP; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany., Ulusoy Ö; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Kraus A; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Hoerenbaum N; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Wolf JN; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Lohmann S; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Zwirnlein F; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Kaygusuz V; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Lakovic V; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Tummes HL; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Beer A; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Gallert M; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Thiebes S; Department of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital Essen, Essen, Germany., Qefalia A; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Cibir Z; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Antler M; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Korste S; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany., Haj Yehia E; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany., Michel L; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany., Rassaf T; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany., Kaltwasser B; Department of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany., Abdelrahman H; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Mohamud Yusuf A; Department of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany., Wang C; Department of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany., Yin D; Department of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany., Haeusler L; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Lueong S; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen), German Cancer Research Center (DKFZ), Heidelberg, Germany., Richter M; Institute for Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), Universität Münster, Münster, Germany., Engel DR; Department of Immunodynamics, Institute of Experimental Immunology and Imaging, University Hospital Essen, Essen, Germany., Stenzel M; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany., Soehnlein O; Institute for Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), Universität Münster, Münster, Germany., Frank B; Department of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany., Solo-Nomenjanahary M; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, U1144 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France., Ho-Tin-Noé B; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, U1144 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France., Siveke JT; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen), German Cancer Research Center (DKFZ), Heidelberg, Germany., Totzeck M; Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University Hospital, University of Duisburg-Essen, Essen, Germany., Hoffmann D; Bioinformatics and Computational Biophysics, Faculty of Biology and Centre for Medical Biotechnology (ZMB), University of Duisburg-Essen, Essen, Germany., Grüneboom A; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany., Hagemann N; Department of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany., Hasenberg A; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany., Desilles JP; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, U1144 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.; Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France., Mazighi M; Optimisation Thérapeutique en Neuropsychopharmacologie, Université Paris Cité, U1144 Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.; Interventional Neuroradiology Department and Biological Resources Center, Rothschild Foundation Hospital, Paris, France., Sickmann A; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany.; Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany.; Department of Chemistry, College of Physical Sciences, University of Aberdeen, Aberdeen, UK., Chen J; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany., Hermann DM; Department of Neurology, University Hospital, University of Duisburg-Essen, Essen, Germany., Gunzer M; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany. matthias.gunzer@uk-essen.de.; Leibniz-Institut für Analytische Wissenschaften - ISAS-e.V., Dortmund, Germany. matthias.gunzer@uk-essen.de., Singh V; Institute for Experimental Immunology and Imaging, University Hospital, University of Duisburg-Essen, Essen, Germany. vikramjeet.singh@uk-essen.de.
Jazyk: angličtina
Zdroj: Nature cardiovascular research [Nat Cardiovasc Res] 2024 May; Vol. 3 (5), pp. 525-540. Date of Electronic Publication: 2024 Apr 23.
DOI: 10.1038/s44161-024-00462-8
Abstrakt: Post-injury dysfunction of humoral immunity accounts for infections and poor outcomes in cardiovascular diseases. Among immunoglobulins (Ig), IgA, the most abundant mucosal antibody, is produced by plasma B cells in intestinal Peyer's patches (PP) and lamina propria. Here we show that patients with stroke and myocardial ischemia (MI) had strongly reduced IgA blood levels. This was phenocopied in experimental mouse models where decreased plasma and fecal IgA were accompanied by rapid loss of IgA-producing plasma cells in PP and lamina propria. Reduced plasma IgG was detectable in patients and experimental mice 3-10 d after injury. Stroke/MI triggered the release of neutrophil extracellular traps (NETs). Depletion of neutrophils, NET degradation or blockade of NET release inhibited the loss of IgA + cells and circulating IgA in experimental stroke and MI and in patients with stroke. Our results unveil how tissue-injury-triggered systemic NET release disrupts physiological Ig secretion and how this can be inhibited in patients.
(© 2024. The Author(s).)
Databáze: MEDLINE
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