| Autor: |
Hennesy HM; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA., Gravely ME; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA., Alambarrio DA; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA., Brannen SR; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA., McDonald JJ; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA., Devane SA; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA., Turner KK; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA., Stelzleni AM; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA., O'Quinn TG; Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506, USA., Gonzalez JM; Department of Animal and Dairy Science, University of Georgia, Athens, GA 30602, USA. |
| Abstrakt: |
The objective of this study was to determine the daily dietary nicotinamide riboside (NR) dose required to maximize the delay of subjective muscle fatigue onset. Barrows ( N = 100) were assigned to one of five treatments: a conventional swine finishing diet containing 0 (CON), 15 (15NR), 30 (30NR), 45 (45NR) mg·kg body weight -1 ·d -1 NR, or CON supplemented with 45 mg·kg body weight -1 ·d -1 NR by drench or cookie dough (DRE). All treatments were administered for the final 11 days of feeding. On supplementation d 10, barrows individually experienced a performance test at 1.09 m/s until they were subjectively exhausted. Wireless electromyography (EMG) sensors were affixed to the biceps femoris (BF), tensor fascia latae (TFL), and semitendinosus (ST) to measure real-time muscle activity. There were no treatment effects for barrow speed ( p = 0.57), a tendency for a treatment effect ( p = 0.07) for distance, and a treatment effect ( p = 0.04) on time to exhaustion. Barrows of the 15NR and DRE treatments had greater ( p = 0.05) distances to exhaustion than CON barrows but did not differ from other NR barrows ( p > 0.11). Barrows in the 45NR treatment did not differ ( p = 0.11) in distance from 30NR barrows but tended to have a greater ( p = 0.07) distance compared to CON barrows. All other treatment comparisons did not differ ( p > 0.27). Barrows in the DRE treatment moved for longer ( p < 0.01) than CON barrows, but all other treatments did not differ from each other ( p > 0.15). There was no treatment × period interaction for all muscles' root mean square (RMS) values ( p > 0.16), but there were Period effects for all muscles ( p < 0.01) and a Treatment effect ( p = 0.04) in the TFL. For all muscles, period 4 had greater RMS values than all other periods ( p < 0.01), who did not differ from each other ( p > 0.29). In the TFL, CON barrows had greater RMS values during the performance test compared to all NR treatments ( p < 0.02), who did not differ from each other ( p > 0.18). Overall, NR demonstrates potential in being a useful tool in fatigue prevention, but efficient administration of the compound needs further investigation. |
