| Autor: |
Relva B; NOVA Medical School, Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal., Samuelsson LM; Smart Foods & Bioproducts Group, AgResearch Ltd., Palmerston North 4442, New Zealand., Duarte IF; Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, Portugal., Fasol U; Faculty of Medical and Life Sciences, Furtwangen University, 78054 Villingen-Schwenningen, Germany., Edwards PJB; School of Natural Sciences, Massey University, Palmerston North 4442, New Zealand., Fogelholm M; Department of Food and Nutrition, University of Helsinki, Unioninkatu 44, 00014 Helsinki, Finland., Raben A; Department of Nutrition, Exercise and Sports, University of Copenhagen, Nørre Allé 51, DK-2200 Copenhagen, Denmark.; Department for Clinical and Translational Research, Copenhagen University Hospital, Steno Diabetes Center Copenhagen, Blegdamsvej 9, DK-2100 Herlev, Denmark., Poppitt SD; Human Nutrition Unit, School of Biological Sciences, Department of Medicine, University of Auckland, 18 Carrick Place, Auckland 1024, New Zealand., Silvestre MP; NOVA Medical School, Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal.; Human Nutrition Unit, School of Biological Sciences, Department of Medicine, University of Auckland, 18 Carrick Place, Auckland 1024, New Zealand.; CINTESIS@RISE, NOVA Medical School, Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal. |
| Abstrakt: |
As obesity develops, metabolic changes increase the risk of non-communicable diseases such as type 2 diabetes (T2D). Weight loss is crucial for improving health in T2D and cardiometabolic conditions. However, weight loss rates vary between individuals, even with identical diets or energy restrictions, highlighting the need to identify markers or predictors of weight loss success to enhance intervention outcomes. Using nuclear magnetic resonance (NMR) spectroscopy-based metabolomics, we investigated the change in serum polar metabolites in 28 women with overweight or obesity and prediabetes who completed an 8-week low-energy diet (LED) as part of the PREVIEW (PREVention of diabetes through lifestyle intervention and population studies in Europe and around the World) clinical trial. We aimed to characterize the metabolic shift in substrate oxidation under fixed energy intake (~4 MJ/day) and its relation to weight loss success. Nine of the thirty-four serum metabolites identified significantly changed during the LED phase: 3-hydroxybutyrate, O -acetylcarnitine, 2-hydroxybutyrate, mannose, dimethyl sulfone and isobutyrate increased, whilst choline, creatine and tyrosine decreased. These results confirmed a shift towards lipid oxidation, but no metabolites predicted the response to the LED-induced weight loss. Further studies in larger populations are required to validate these metabolites as biomarkers of diet exposure. |
