Capsaicin: Emerging Pharmacological and Therapeutic Insights.

Autor:	Petran EM; Department of Biochemistry, The 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Toxicology, Grigore Alexandrescu Emergency Children's Hospital, 011743 Bucharest, Romania., Periferakis A; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Akadimia of Ancient Greek and Traditional Chinese Medicine, 16675 Athens, Greece.; Elkyda, Research & Education Centre of Charismatheia, 17675 Athens, Greece., Troumpata L; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Periferakis AT; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Elkyda, Research & Education Centre of Charismatheia, 17675 Athens, Greece., Scheau AE; Department of Radiology and Medical Imaging, Fundeni Clinical Institute, 022328 Bucharest, Romania., Badarau IA; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania., Periferakis K; Akadimia of Ancient Greek and Traditional Chinese Medicine, 16675 Athens, Greece.; Pan-Hellenic Organization of Educational Programs (P.O.E.P), 17236 Athens, Greece., Caruntu A; Department of Oral and Maxillofacial Surgery, The 'Carol Davila' Central Military Emergency Hospital, 010825 Bucharest, Romania.; Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, 'Titu Maiorescu' University, 031593 Bucharest, Romania., Savulescu-Fiedler I; Department of Internal Medicine, The 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Internal Medicine and Cardiology, Coltea Clinical Hospital, 030167 Bucharest, Romania., Sima RM; Department of Obstetrics and Gynecology, The 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.; The 'Bucur' Maternity, 'Saint John' Hospital, 040294 Bucharest, Romania., Calina D; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania., Constantin C; Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania.; Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania., Neagu M; Immunology Department, Victor Babes National Institute of Pathology, 050096 Bucharest, Romania.; Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania.; Faculty of Biology, University of Bucharest, 76201 Bucharest, Romania., Caruntu C; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Dermatology, 'Prof. N.C. Paulescu' National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, Romania., Scheau C; Department of Physiology, The 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.; Department of Radiology and Medical Imaging, 'Foisor' Clinical Hospital of Orthopaedics, Traumatology and Osteoarticular TB, 021382 Bucharest, Romania.
Jazyk:	angličtina
Zdroj:	Current issues in molecular biology [Curr Issues Mol Biol] 2024 Jul 24; Vol. 46 (8), pp. 7895-7943. Date of Electronic Publication: 2024 Jul 24.
DOI:	10.3390/cimb46080468
Abstrakt:	Capsaicin, the most prominent pungent compound of chilli peppers, has been used in traditional medicine systems for centuries; it already has a number of established clinical and industrial applications. Capsaicin is known to act through the TRPV1 receptor, which exists in various tissues; capsaicin is hepatically metabolised, having a half-life correlated with the method of application. Research on various applications of capsaicin in different formulations is still ongoing. Thus, local capsaicin applications have a pronounced anti-inflammatory effect, while systemic applications have a multitude of different effects because their increased lipophilic character ensures their augmented bioavailability. Furthermore, various teams have documented capsaicin's anti-cancer effects, proven both in vivo and in vitro designs. A notable constraint in the therapeutic effects of capsaicin is its increased toxicity, especially in sensitive tissues. Regarding the traditional applications of capsaicin, apart from all the effects recorded as medicinal effects, the application of capsaicin in acupuncture points has been demonstrated to be effective and the combination of acupuncture and capsaicin warrants further research. Finally, capsaicin has demonstrated antimicrobial effects, which can supplement its anti-inflammatory and anti-carcinogenic actions.
Databáze:	MEDLINE
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