Gut microbiota alterations in renal transplant recipients and the risk of urinary tract infection and delayed graft function: A preliminary prospective study.
| Autor: | Jelveh Moghaddam E; Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Pourmand G; Urology Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Ahmadi Badi S; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran., Yarmohammadi H; Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran., Soltanipur M; Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Quality of Life Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran.; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran., Mahalleh M; Department of Urology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran., Rezaei M; Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran., Mirhosseini SM; Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Siadat SD; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.; Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Urologia [Urologia] 2024 Nov; Vol. 91 (4), pp. 781-787. Date of Electronic Publication: 2024 Aug 28. |
| DOI: | 10.1177/03915603241276742 |
| Abstrakt: | Background: The implication of gut microbiota in the gut-kidney axis affects the pathophysiology of chronic kidney disease (CKD). Gut microbiota composition changes during CKD. We aimed to determine the relative frequency of important gut microbiota members in end-stage renal disease (ERSD) patients before and after renal transplantation compared to healthy subjects. Methods: Fifteen kidney transplant patients and 10 healthy subjects were recruited in this case-control prospective study. Fecal samples were taken sequentially from all patients before kidney transplantation, 1 week, and 1 month after it. The relative frequency of Lactobacillus spp., Bifidobacterium spp., Akkermansia muciniphila, Bacteroides fragilis, Escherichia coli , and Faecalibacterium pruasnitzii were determined through quantitative PCR. The obtained data was statistically analyzed by Stata software (Stata Corporation, USA). Results: The mean log number of all bacteria was significantly higher in healthy individuals than kidney transplant recipients ( p < 0.001) except for Lactobacillus where the mean levels were almost identical in the two groups ( p = 0.67). Moreover, 20% (3) of patients developed a urinary tract infection. Besides, 2 (13.33%) patients were diagnosed with delayed graft function. There were no statistically significant differences regarding changing trends in bacteria log number of Akkermansia muciniphila ( p = 0.12), Bacteroid fragilis ( p = 0.75), Bifidobacterium ( p = 0.99), Escherichia coli ( p = 0.5), Faecalibacterium ( p = 0.98), and Lactobacilli ( p = 0.93) between patients with and without delayed graft function (DGF). Conclusion: Gut microbiota composition in patients with ESRD was significantly different from those without it. However, the microbiota profile did not significantly differ in patients with and without DGF. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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