[Analysis of Factors Influencing Overall Survival and Prognosis of AML Patients Over 50 Years Old].

Autor:	Liu H; Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Key Laboratory of Hematology,Nanjing Medical University.Huai'an 223300, Jiangsu Province, China., Li Z; Department of Breast and Thyroid Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, China., Shi YY; Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Key Laboratory of Hematology,Nanjing Medical University.Huai'an 223300, Jiangsu Province, China., Tao SD; Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Key Laboratory of Hematology,Nanjing Medical University.Huai'an 223300, Jiangsu Province, China., Wang CL; Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Key Laboratory of Hematology,Nanjing Medical University.Huai'an 223300, Jiangsu Province, China., Yu L; Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Key Laboratory of Hematology,Nanjing Medical University.Huai'an 223300, Jiangsu Province, China.E-mail: yuliangha@163.com.
Jazyk:	čínština
Zdroj:	Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2024 Aug; Vol. 32 (4), pp. 1039-1045.
DOI:	10.19746/j.cnki.issn.1009-2137.2024.04.010
Abstrakt:	Objective: To explore the overall survival and prognostic factors of patients over 50 years old with acute myeloid leukemia (AML). Methods: The clinical data of 222 AML patients aged over 50 years in our hospital from January 2016 and June 2021 were retrospectively analyzed. Kaplan-Meier method was used to evaluate the overall survival (OS) rate, and Cox regression model to evaluate the prognostic factors. Results: The 1-year and 3-year OS rates of all patients were 46.8% and 28.8%, respectively. The recurrence rate of patients who achieved remission during follow-up time was 57%. Both univariate and multivariate analysis showed that advanced age, MLL family fusion gene, PHF6 gene mutation, TP53 gene mutation, intolerance to standard chemotherapy, incomplete remission, complex karyotype, +mar karyotype and inv(3) karyotype were significantly correlated with prognosis (all P <0.05). Negative fusion gene and positive AML- ETO fusion gene had no obvious survival advantage in this population. In patients with complete remission, there was no significant survival advantage in those who achieved minimal residual disease negative. Conclusion: AML patients aged over 50 years have a poor outcome and high recurrence rate. The prognosis is affected by multiple factors and has its own characteristics.
Databáze:	MEDLINE
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