HerpesDRG: a comprehensive resource for human herpesvirus antiviral drug resistance genotyping.

Autor: Charles OJ; Department of Infection, Immunity and Inflammation, University College London, Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK. oscar.charles.18@ucl.ac.uk., Venturini C; Department of Infection, Immunity and Inflammation, University College London, Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK., Goldstein RA; Division of Infection and Immunity, University College London, London, WC1E 6BT, UK., Breuer J; Department of Infection, Immunity and Inflammation, University College London, Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; Great Ormond Street Hospital for Children National Health Service Foundation Trust, London, WC1N 1LE, UK.
Jazyk: angličtina
Zdroj: BMC bioinformatics [BMC Bioinformatics] 2024 Aug 27; Vol. 25 (1), pp. 279. Date of Electronic Publication: 2024 Aug 27.
DOI: 10.1186/s12859-024-05885-5
Abstrakt: The prevention and treatment of many herpesvirus associated diseases is based on the utilization of antiviral therapies, however therapeutic success is limited by the development of drug resistance. Currently no single database cataloguing resistance mutations exists, which hampers the use of sequence data for patient management. We therefore developed HerpesDRG, a drug resistance mutation database that incorporates all the known resistance genes and current treatment options, built from a systematic review of available genotype to phenotype literature. The database is released along with an R package that provides a simple approach to resistance variant annotation and clinical implication analysis from common sanger and next generation sequencing data. This represents the first openly available and community maintainable database of drug resistance mutations for the human herpesviruses (HHV), developed for the community of researchers and clinicians tackling HHV drug resistance.
(© 2024. The Author(s).)
Databáze: MEDLINE
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