High-intensity resistance training improves quality of life, muscle endurance and strength in patients with myositis: a randomised controlled trial.

Autor: Jensen KY; Copenhagen Research Center for Autoimmune Connective Tissue Diseases (COPEACT), Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark. kasper.yde.jensen@regionh.dk., Aagaard P; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark., Suetta C; Geriatric Research Unit, Department of Geriatric and Palliative Medicine, Copenhagen University Hospital, Bispebjerg, Frederiksberg, Denmark.; Department of Clinical Medicine, Faculty of Health and Health Sciences, University of Copenhagen, Copenhagen, Denmark., Nielsen JL; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark., Bech RD; Department of Orthopaedics and Traumatology, Zealand University Hospital, Koege, Denmark., Schrøder HD; Department of Pathology, Odense University Hospital, Odense, Denmark., Christensen J; Department of Occupational Therapy and Physiotherapy, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Simonsen C; Centre for Physical Activity Research, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark., Diederichsen LP; Copenhagen Research Center for Autoimmune Connective Tissue Diseases (COPEACT), Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark.; Department of Rheumatology, Odense University Hospital, Odense, Denmark.
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2024 Oct; Vol. 44 (10), pp. 1909-1921. Date of Electronic Publication: 2024 Aug 27.
DOI: 10.1007/s00296-024-05698-y
Abstrakt: Myositis is associated with reduced quality of life, which is accompanied by significant impairments in muscle endurance and strength, altogether representing cardinal traits in patients with myositis. This randomised controlled trial aimed to investigate the effect of high-intensity resistance training on quality of life in patients with myositis. Thirty-two patients with established, stable myositis were randomised to 16 weeks of high-intensity resistance training (intervention group) or 16 weeks of usual care (control group). Primary outcome was quality of life assessed as the change in the physical component summary score (PCS) of the Short Form-36 health questionnaire from baseline to post-intervention. Secondary outcomes included functional capacity measures, such as functional index 3, and International Myositis Assessment and Clinical Studies Group (IMACS) disease activity and damage core set measures, including manual muscle testing 8 (MMT8). The primary outcome PCS showed an improvement in favour of high-intensity resistance training with a between-group difference of 5.33 (95% CI 0.61; 10.05) (p = 0.03). Additionally, functional index 3 showed a between-group difference indicating greater gains with high-intensity resistance training 11.49 (95% CI 3.37; 19.60) (p = 0.04), along with a between-group improvement in MMT8 1.30 (95% CI 0.09; 2.51) (p = 0.04). High-intensity resistance training for 16 weeks effectively improved quality of life in patients with myositis. Clinical measures of muscle endurance and muscle strength were also found to improve with high-intensity resistance training, while patients stayed in disease remission. Consequently, progressively adjusted high-intensity resistance training is feasible and causes no aggravation of the disease, while benefitting patients with myositis.Clinical trial registration: Clinicaltrials.gov ID: NCT04486261- https://clinicaltrials.gov/study/NCT04486261 .
(© 2024. The Author(s).)
Databáze: MEDLINE
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