Worse Wilms' Tumor Outcomes Associated With Chemical Complementarity for Multiple T-Cell Receptor CDR3-CMV Epitope Pairs.

Autor:	Rigby KL; University of Central Florida College of Medicine, Orlando, FL, U.S.A., Diaz MJ; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A., Gozlan EC; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A., Kacsoh DB; University of Central Florida College of Medicine, Orlando, FL, U.S.A., Song JJ; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A., Hudock TR; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A., Chobrutskiy A; Department of Pediatrics, Oregon Health and Science University Hospital, Portland, OR, U.S.A., Chobrutskiy BI; Department of Internal Medicine, Oregon Health and Science University Hospital, Portland, OR, U.S.A., Blanck G; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, U.S.A.; gblanck@usf.edu.; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A.
Jazyk:	angličtina
Zdroj:	Cancer genomics & proteomics [Cancer Genomics Proteomics] 2024 Sep-Oct; Vol. 21 (5), pp. 439-447.
DOI:	10.21873/cgp.20462
Abstrakt:	Background/aim: Wilms' tumors are pediatric renal tumors that generally have a good prognosis and outcomes. Viral illnesses have been linked to development of neoplasms and should be considered as a factor that could modulate overall survival. Materials and Methods: We considered recently developed adaptive immune receptor, genomics and bioinformatics approaches to assess the potential impact of cytomegalovirus (CMV) infections in Wilms' tumor. Results: T-cell receptor (TCR) complementarity determining region-3 (CDR3) amino acid sequences from Wilms' tumor specimens represented by the Therapeutically Applicable Research to Generate Effective Treatments dataset were compared with known anti-CMV TCR CDR3s, indicating that cases representing the anti-CMV TCR CDR3s had worse outcomes. Then, a chemical complementarity scoring approach for the Wilms' tumor, TCR CDR3s and a series of CMV antigens further indicated that cases representing a higher chemical complementarity to the CMV antigens had worse outcomes. Conclusion: Overall, we present a potentially novel method to assess CMV infections and identify patients who could benefit from therapies that address such infections. (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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