Food-breastmilk combinations alter the colonic microbiome of weaning infants: an in silico study.

Autor:	da Silva VG; Riddet Institute, Massey University, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand., Smith NW; Riddet Institute, Massey University, Palmerston North, New Zealand., Mullaney JA; Riddet Institute, Massey University, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand.; AgResearch, Palmerston North, New Zealand., Wall C; High-Value Nutrition National Science Challenge, Auckland, New Zealand.; Department of Nutrition and Dietetics, The University of Auckland, Auckland, New Zealand., Roy NC; Riddet Institute, Massey University, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand.; Department of Human Nutrition, University of Otago, Dunedin, New Zealand., McNabb WC; Riddet Institute, Massey University, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
Jazyk:	angličtina
Zdroj:	MSystems [mSystems] 2024 Sep 17; Vol. 9 (9), pp. e0057724. Date of Electronic Publication: 2024 Aug 27.
DOI:	10.1128/msystems.00577-24
Abstrakt:	The introduction of solid foods to infants, also known as weaning, is a critical point for the development of the complex microbial community inhabiting the human colon, impacting host physiology in infancy and later in life. This research investigated in silico the impact of food-breastmilk combinations on growth and metabolite production by colonic microbes of New Zealand weaning infants using the metagenome-scale metabolic model named Microbial Community. Eighty-nine foods were individually combined with breastmilk, and the 12 combinations with the strongest influence on the microbial production of short-chain fatty acids (SCFAs) and branched-chain fatty acids (BCFAs) were identified. Fiber-rich and polyphenol-rich foods, like pumpkin and blackcurrant, resulted in the greatest increase in predicted fluxes of total SCFAs and individual fluxes of propionate and acetate when combined, respectively, with breastmilk. Identified foods were further combined with other foods and breastmilk, resulting in 66 multiple food-breastmilk combinations. These combinations altered in silico the impact of individual foods on the microbial production of SCFAs and BCFAs, suggesting that the interaction between the dietary compounds composing a meal is the key factor influencing colonic microbes. Blackcurrant combined with other foods and breastmilk promoted the greatest increase in the production of acetate and total SCFAs, while pork combined with other foods and breastmilk decreased the production of total BCFAs.IMPORTANCELittle is known about the influence of complementary foods on the colonic microbiome of weaning infants. Traditional in vitro and in vivo microbiome methods are limited by their resource-consuming concerns. Modeling approaches represent a promising complementary tool to provide insights into the behavior of microbial communities. This study evaluated how foods combined with other foods and human milk affect the production of short-chain fatty acids and branched-chain fatty acids by colonic microbes of weaning infants using a rapid and inexpensive in silico approach. Foods and food combinations identified here are candidates for future experimental investigations, helping to fill a crucial knowledge gap in infant nutrition. Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu