Nitric oxide-triggering activity of gold-, platinum- and cerium oxide-nanozymes from S-nitrosothiols and diazeniumdiolates.

Autor: Jansman MMT; Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, Kgs. Lyngby 2800, Denmark., Norkute E; Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, Kgs. Lyngby 2800, Denmark., Jin W; Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, Kgs. Lyngby 2800, Denmark., Kempen PJ; Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, Kgs. Lyngby 2800, Denmark; DTU Nanolab, National Center for Nano Fabrication and Characterization Technical University of Denmark, Ørsteds Plads, Building 347, Kgs. Lyngby 2800, Denmark., Douka D; Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, Kgs. Lyngby 2800, Denmark., Thulstrup PW; Department of Chemistry, University of Copenhagen, Universitetsparken 5, Copenhagen 2100, Denmark., Hosta-Rigau L; Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark, Nils Koppels Allé, Building 423, Kgs. Lyngby 2800, Denmark. Electronic address: leri@dtu.dk.
Jazyk: angličtina
Zdroj: Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Dec; Vol. 244, pp. 114161. Date of Electronic Publication: 2024 Aug 12.
DOI: 10.1016/j.colsurfb.2024.114161
Abstrakt: Cardiovascular diseases pose a significant global health challenge, contributing to high mortality rates and impacting overall well-being and quality of life. Nitric oxide (NO) plays a pivotal role as a vasodilator, regulating blood pressure and enhancing blood flow-crucial elements in preventing cardiovascular diseases, making it a prime therapeutic target. Herein, metal-based nanozymes (NZs) designed to induce NO release from both endogenous and exogenous NO-donors are investigated. Successful synthesis of gold, platinum (Pt) and cerium oxide NZs is achieved, with all three NZs demonstrating the ability to catalyze the NO release from various NO sources, namely S-nitrosothiols and diazeniumdiolates. Pt-NZs exhibit the strongest performance among the three NZ types. Further exploration involved investigating encapsulation and coating techniques using poly(lactic-co-glycolic acid) nanoparticles as experimental carriers for Pt-NZs. Both strategies showed efficiency in serving as platforms for Pt-NZs, successfully showing the ability to trigger NO release.
Competing Interests: Declaration of Competing Interest The authors declare no conflicts of interest. The funders had no role in the design of the study nor in the decision to publish the results.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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