The effects of physiologically relevant environmental conditions on the mechanical properties of 3D-printed biopolymer nanocomposites.

Autor: Diederichs EV; Waterloo Composite Biomaterial Systems Laboratory, Department of Systems Design Engineering, University of Waterloo, 200 University Avenue West, Waterloo, Canada., Mondal D; Waterloo Composite Biomaterial Systems Laboratory, Department of Systems Design Engineering, University of Waterloo, 200 University Avenue West, Waterloo, Canada., Willett TL; Waterloo Composite Biomaterial Systems Laboratory, Department of Systems Design Engineering, University of Waterloo, 200 University Avenue West, Waterloo, Canada. Electronic address: thomas.willett@uwaterloo.ca.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Nov; Vol. 159, pp. 106694. Date of Electronic Publication: 2024 Aug 20.
DOI: 10.1016/j.jmbbm.2024.106694
Abstrakt: The demand for synthetic bone graft biomaterials has grown in recent years to alleviate the dependence on natural bone grafts and metal prostheses which are associated with significant practical and clinical issues. Biopolymer nanocomposites are a class of materials that display strong potential for these synthetic materials, especially when processed using additive manufacturing technologies. Novel nanocomposite biomaterials capable of masked stereolithography printing have been developed from functionalized plant-based monomers and hydroxyapatite (HA) with mechanical properties exceeding those of commercial bone cements. However, these biomaterials have not been evaluated under relevant physiological conditions. The effects of temperature (room temperature vs. 37 °C) and water absorption on the physical, surface, and mechanical properties of HA-containing biopolymer nanocomposites were investigated. Exposure to relevant conditions led to substantial impacts on material performance, such as significantly reduced mechanical strength and stiffness. For instance, a composite containing 10 vol% HA and functionalized monomers had 26 and 21% reductions in compressive yield strength and elastic modulus, respectively. After 14 days incubation in phosphate buffered saline, the same composition displayed a 62% decrease in compressive yield strength to 28 MPa. This manuscript demonstrates the relevance and importance of evaluating biomaterials under appropriate physiological conditions throughout their development and provides direction for future material development of HA-containing biopolymer nanocomposites.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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