Host-microbial interactions differ with age of asthma onset.

Autor: Versi A; National Heart and Lung Institute and Data Science Institute, Imperial College London, London, UK., Azim A; Faculty of Medicine, Southampton University, Southampton, UK., Ivan FX; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Abdel-Aziz MI; Amsterdam University Medical Centers, Department of Pulmonary Medicine, University of Amsterdam, Amsterdam, The Netherlands., Bates S; Respiratory Therapeutic Unit, GSK, Stockley Park, UK., Riley J; Respiratory Therapeutic Unit, GSK, Stockley Park, UK., Maitland-Van Der Zee AH; Amsterdam University Medical Centers, Department of Pulmonary Medicine, University of Amsterdam, Amsterdam, The Netherlands., Dahlen SE; Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Djukanovic R; Faculty of Medicine, Southampton University, Southampton, UK., Chotirmall SH; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, Singapore, Singapore., Howarth P; Faculty of Medicine, Southampton University, Southampton, UK., Kermani NZ; National Heart and Lung Institute and Data Science Institute, Imperial College London, London, UK., Chung KF; National Heart and Lung Institute and Data Science Institute, Imperial College London, London, UK., Adcock IM; National Heart and Lung Institute and Data Science Institute, Imperial College London, London, UK ian.adcock@imperial.ac.uk.
Jazyk: angličtina
Zdroj: The European respiratory journal [Eur Respir J] 2024 Sep 05; Vol. 64 (3). Date of Electronic Publication: 2024 Sep 05 (Print Publication: 2024).
DOI: 10.1183/13993003.00428-2024
Abstrakt: Competing Interests: Conflict of interest: A. Azim is a paid employee of AstraZeneca, and holds stock or stock options in AstraZeneca. S. Bates is an employee of and holds stock in Johnson & Johnson. S. Bates previously worked for and holds stock in GSK. J. Riley previously worked for and held stock in GSK. A.H. Maitland-Van Der Zee reports grants from Health Holland, GSK, Boehringer Ingelheim and Vertex, consultancy fees from Boehringer Ingelheim and AstraZeneca, payment or honoraria for lectures, presentations, manuscript writing or educational events from GSK, and participation on a data safety monitoring board or advisory board for a study on BPD in neonates. S-E. Dahlen reports support for the present study from EU funding through IMI, grants from AstraZeneca, Cayman Chemical, GSK and Sanofi, consultancy fees from AstraZeneca, GSK and Sanofi, payment or honoraria for lectures, presentations, manuscript writing or educational events from AstraZeneca and Sanofi, and a leadership role with 3TR IMI as a Steering Board member. R. Djukanovic reports consultancy fees from Synairgen plc, GSK, ZenasBio and Celltrion, a leadership role with the European Respiratory Society's Clinical collaboration on severe asthma (SHARP) as Chair, and stock (or stock options) with Synairgen. S.H. Chotirmall reports support for the present manuscript from the Singapore Ministry of Health's National Medical Research Council under its Clinician-Scientist Individual Research Grant (MOH-001356), the Singapore Ministry of Health's National Medical Research Council under its Clinician Scientist Award (MOH-000710), consultancy fees from CSL Behring, Boehringer Ingelheim and Pneumagen Ltd, payment or honoraria for lectures, presentations, manuscript writing or educational events from AstraZeneca and Chiesi Farmaceutici, and participation on a data safety monitoring board or advisory board with Inovio Pharmaceuticals Inc., Imam Abdulrahman Bin Faisal University. P. Howarth is an employee of GSK. N.Z. Kermani reports support for the present study from Data Science Institute, Imperial College London, National Heart and Lung Institute, Imperial College London. K.F. Chung reports grants from MRC, EPSRC, GSK, Merck and NIEHS, payment or honoraria for lectures, presentations, manuscript writing or educational events from GSK, Novartis and AZ, participation on a data safety monitoring board or advisory board with GSK, AZ, Novartis, Roche, Merck, Trevi, Rickett-Beckinson, Nocion and Shionogi Clean Breathing Institute supported by Haleon. I.M. Adcock reports support for the present study from EU funding through IMI, grants from GSK, MRC, EPSRC and Sanofi, consultancy fees from GSK, Sanofi and Kinaset, and payment or honoraria for lectures, presentations, manuscript writing or educational events from AstraZeneca and Sanofi. The remaining authors have no potential conflicts of interest to disclose.
Databáze: MEDLINE