A neural network for religious fundamentalism derived from patients with brain lesions.

Autor:	Ferguson MA; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Asp EW; Department of Neurology, University of Iowa, Iowa City, IA 52242.; Department of Psychology, Hamline University, St. Paul, MN 55104.; Wesley and Lorene Artz Cognitive Neuroscience Research Center, Department of Psychology, Hamline University, St. Paul, MN 55104., Kletenik I; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Tranel D; Department of Neurology, University of Iowa, Iowa City, IA 52242.; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA 52242., Boes AD; Department of Neurology, University of Iowa, Iowa City, IA 52242.; Department of Psychiatry, University of Iowa, Iowa City, IA 52242.; Department of Pediatrics, University of Iowa, Iowa City, IA 52242., Nelson JM; Department of Psychology and Neuroscience, Baylor University, Waco, TX 76706., Schaper FLWVJ; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Siddiqi S; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Turner JI; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Anderson JS; Department of History, Boston University, Boston, MA 02215., Nielsen JA; Department of Psychology, Brigham Young University, Provo, UT 04602., Bateman JR; Department of Neurology, Wake Forest School of Medicine, Winston-Salem, NC 27101.; Mental Illness Research, Education, and Clinical Center, Salisbury Veterans Affairs Medical Center, Salisbury, NC 28144., Grafman J; Department of Physical Medicine and Rehabilitation, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Department of Psychiatry, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.; Shirley Ryan AbilityLab, Chicago, IL 60611., Fox MD; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Jazyk:	angličtina
Zdroj:	Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Sep 03; Vol. 121 (36), pp. e2322399121. Date of Electronic Publication: 2024 Aug 27.
DOI:	10.1073/pnas.2322399121
Abstrakt:	Religious fundamentalism, characterized by rigid adherence to a set of beliefs putatively revealing inerrant truths, is ubiquitous across cultures and has a global impact on society. Understanding the psychological and neurobiological processes producing religious fundamentalism may inform a variety of scientific, sociological, and cultural questions. Research indicates that brain damage can alter religious fundamentalism. However, the precise brain regions involved with these changes remain unknown. Here, we analyzed brain lesions associated with varying levels of religious fundamentalism in two large datasets from independent laboratories. Lesions associated with greater fundamentalism were connected to a specific brain network with nodes in the right orbitofrontal, dorsolateral prefrontal, and inferior parietal lobe. This fundamentalism network was strongly right hemisphere lateralized and highly reproducible across the independent datasets ( r = 0.82) with cross-validations between datasets. To explore the relationship of this network to lesions previously studied by our group, we tested for similarities to twenty-one lesion-associated conditions. Lesions associated with confabulation and criminal behavior showed a similar connectivity pattern as lesions associated with greater fundamentalism. Moreover, lesions associated with poststroke pain showed a similar connectivity pattern as lesions associated with lower fundamentalism. These findings are consistent with the current understanding of hemispheric specializations for reasoning and lend insight into previously observed epidemiological associations with fundamentalism, such as cognitive rigidity and outgroup hostility. Competing Interests: Competing interests statement:The authors declare no competing interest.
Databáze:	MEDLINE
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