Hepatitis B vaccine responders show higher frequencies of CD8 + effector memory and central memory T cells compared to non-responders.

Autor: Vakili ME; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Mashhadi N; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Ataollahi MR; Department of Immunology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran., Meri S; Department of Bacteriology and Immunology and the Translational Immunology Research Program (TRIMM), Helsinki University Hospital, The University of Helsinki and HUSLAB, Helsinki, Finland., Kabelitz D; Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig, Holstein Campus Kiel, Kiel, Germany., Kalantar K; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.; Department of Bacteriology and Immunology and the Translational Immunology Research Program (TRIMM), Helsinki University Hospital, The University of Helsinki and HUSLAB, Helsinki, Finland.; Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Jazyk: angličtina
Zdroj: Scandinavian journal of immunology [Scand J Immunol] 2024 Nov; Vol. 100 (5), pp. e13402. Date of Electronic Publication: 2024 Aug 27.
DOI: 10.1111/sji.13402
Abstrakt: Hepatitis B (HB) infection is a major global health problem. There is limited knowledge about HB vaccination-induced immune memory responses. We compared the frequency of CD8 + memory T cell subsets between responders (RSs) and non-responders (NRs) to HB vaccination. Blood samples were collected from RSs and NRs. PBMCs were cultured in the presence of Hepatitis B surface antigens (HBsAg) and PHA for 48 h to restimulate CD8 + memory T cells and T cell memory subsets were detected by flow cytometry using memory cell markers. The frequency of T EM , T CM , and T CM hi was significantly higher in responders compared to non-responders (p = 0.024, 0.022, and 0.047, respectively). Additionally, we report a positive correlation between the frequency of T EM cells in RSs with age and anti-HBsAb level (p = 0.03 and r s  = 0.5; p = 0.01 and r s  = 0.06). Responders display a higher level of CD8 + T cell-mediated immunity. Therefore, we suggest a possible defect in the formation of immunological CD8 + memory T cells in NRs and it may reduce antibody production compared to the RSs, although more experiments are needed.
(© 2024 The Scandinavian Foundation for Immunology.)
Databáze: MEDLINE
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