Intra- and interindividual variability in fasted gastric content volume.

Autor: Roelofs JJM; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Camps G; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Leenders LM; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Marciani L; Nottingham Digestive Diseases Centre, NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK., Spiller RC; Nottingham Digestive Diseases Centre, NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK., Van Eijnatten EJM; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Alyami J; Nottingham Digestive Diseases Centre, NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.; Radiological Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia., Deng R; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Freitas D; Université Paris-Saclay, INRAE, AgroParisTech, UMR SayFood, Thiverval-Grignon, France., Grimm M; Institute of Pharmacy, Center of Drug Absorption and Transport, University of Greifswald, Greifswald, Germany., Karhunen LJ; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Krishnasamy S; Nottingham Digestive Diseases Centre, NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK., Le Feunteun S; INRAE, Institut Agro, Rennes, France., Lobo DN; Nottingham Digestive Diseases Centre, NIHR Nottingham Biomedical Research Centre (BRC), Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.; Division of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Mackie AR; Food Colloids and Processing Group, School of Food Science and Nutrition, University of Leeds, Leeds, UK., Mayar M; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands., Weitschies W; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Smeets PAM; Division of Human Nutrition and Health, Wageningen University, Wageningen, The Netherlands.
Jazyk: angličtina
Zdroj: Neurogastroenterology and motility [Neurogastroenterol Motil] 2024 Nov; Vol. 36 (11), pp. e14904. Date of Electronic Publication: 2024 Aug 27.
DOI: 10.1111/nmo.14904
Abstrakt: Background: Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics.
Methods: Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. The analysis included 366 participants who had up to 6 repeated measurements, with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra- and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI).
Results: FGCV ranged from 0 to 156 mL, with a mean (± SD) value of 33 ± 25 mL. The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: -6 mL), when corrected for the aforementioned factors.
Conclusion: FGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day-to-day and within-day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied.
(© 2024 The Author(s). Neurogastroenterology & Motility published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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