| Autor: |
Kaimal A; Biomedical and Translational Sciences Institute, Neuroscience Division, University of Georgia, Athens, GA 30602, USA., Hooversmith JM; Biomedical and Translational Sciences Institute, Neuroscience Division, University of Georgia, Athens, GA 30602, USA., Mansi MHA; Department of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA., Holmes PV; Biomedical and Translational Sciences Institute, Neuroscience Division, University of Georgia, Athens, GA 30602, USA., MohanKumar PS; Department of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA., MohanKumar SMJ; Department of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. |
| Abstrakt: |
This study examines the sex-specific effects of gestational exposure (days 6-21) to endocrine-disrupting chemicals such as bisphenol A (BPA), diethylhexyl phthalate (DEHP), or their combination on brain monoamine levels that play an important role in regulating behavior. Pregnant Sprague-Dawley rats were orally administered saline, low doses (5 µg/kg BW/day) of BPA or DEHP, and their combination or a high dose (7.5 mg/kg BW/day) of DEHP alone or in combination with BPA during pregnancy. The offspring were subjected to a behavioral test and sacrificed in adulthood, and the brains were analyzed for neurotransmitter levels. In the paraventricular nucleus, there was a marked reduction in dopamine levels ( p < 0.01) in male offspring from the BPA, DEHP, and B + D (HD) groups, which correlated well with their shock probe defensive burying times. Neurotransmitter changes in all brain regions examined were significant in female offspring, with DEHP (HD) females being affected the most, followed by the B + D groups. BPA and/or DEHP (LD) increased monoamine turnover in a region-specific manner in male offspring ( p < 0.05). Overall, prenatal exposure to BPA, DEHP, or their combination alters monoamine levels in a brain region-specific, sex-specific, and dose-dependent manner, which could have implications for their behavioral and neuroendocrine effects. |
