Association between TMPRSS2 rs2070788 polymorphism and COVID-19 severity: a case-control study in multiple cities of Iran.

Autor:	Faridzadeh A; Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Mahmoudi M; Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Rahimlou B; Immunoregulation Research Center, Shahed University, Tehran, Iran., Naghizadeh MM; Non-Communicable Diseases Research Center, Fasa University of Medical Science, Fasa, Iran., Ghazanfari T; Immunoregulation Research Center, Shahed University, Tehran, Iran.; Department of Immunology, Shahed University, Tehran, Iran.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2024 Aug 12; Vol. 11, pp. 1425916. Date of Electronic Publication: 2024 Aug 12 (Print Publication: 2024).
DOI:	10.3389/fmed.2024.1425916
Abstrakt:	Introduction: Host genetic variations have been identified as potential influencers of COVID-19 infection. This study aimed to examine the association between transmembrane serine protease type 2 ( TMPRSS2 ) rs2070788 single nucleotide polymorphism (SNP) and the prognosis of COVID-19 in Iranian populations. Method: This case-control study was performed on 756 COVID-19 patients and 59 healthy individuals across Iran. Clinical data, blood samples, and the presence of the TMPRSS2 rs2070788: G>A SNP were determined using T-ARMS-PCR. Additionally, serum levels of tumor necrosis factor α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), and IL-1β were evaluated in the collected blood samples. Results: No significant association was found between the genotypes and allele frequencies of TMPRSS2 rs2070788 SNP and susceptibility to or mortality from COVID-19 infection. However, we observed a substantial increase in IL-6 and CRP levels associated with the severity of COVID-19, while no such trend was observed for IL-1β and TNF-α. This study showed a considerable rise in TNF-α and IL-1β serum levels exclusively in COVID-19 patients with TT rs2070788 TMPRSS2 SNP genotype compared to healthy controls. Conclusion: In this study conducted across multiple cities in Iran, no significant association was found between the TMPRSS2 rs2070788 SNP genotypes and COVID-19 severity or mortality. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Faridzadeh, Mahmoudi, Rahimlou, Naghizadeh and Ghazanfari.)
Databáze:	MEDLINE
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