Clinical Impact of C-myc Oncogenic Diversity on Solid and Lymphoid Malignancies.

Autor: Papouliakos S; Department of Otolaryngology,''Gennimatas'' GNA Hospital, Athens, Greece., Chrysovergis A; Department of Otolaryngology, ''ELPIS'' GNA Hospital, Athens, Greece., Papanikolaou V; Department of Otolaryngology, ''Sotiria'' GNA Hospital, Athens, Greece., Spyropoulou D; Department of Radiation Oncology, Medical School, University of Patras, Patras, Greece., Papanastasiou G; Department of Otorhinolaryngology, Head and Neck Surgery, Lausanne University Hospital, Lausanne, Switzerland; Department of Maxillofacial Surgery, Medical School, University of Ioannina, Ioannina, Greece., Asimakopoulos AD; Department of Otorhinolaryngology, Head and Neck Surgery, Lausanne University Hospital, Lausanne, Switzerland; Department of Maxillofacial Surgery, Medical School, University of Ioannina, Ioannina, Greece., Mastronikoli S; Brighton and Sussex Medical School, Brighton, UK., Stathopoulos P; Department of Maxillofacial Surgery, 'KAT', GNA Hospital, Athens, Greece., Roukas D; Department of Psychiatry, 417 Veterans Army Hospital, Athens, Greece., Adamopoulou M; Biomedical Sciences Program, Department of Science and Mathematics, Deree American College, Athens, Greece., Tsiambas E; Department of Cytology, 417 Veterans Army Hospital, Athens, Greece., Peschos D; Department of Physiology, Medical School, University of Ioannina, Greece., Pantos P; First Department of Otolaryngology, 'Hippocration' Hospital, Medical school, National and Kapodistrian University of Athens, Athens, Greece., Ragos V; Department of Otorhinolaryngology, Head and Neck Surgery, Lausanne University Hospital, Lausanne, Switzerland; Department of Maxillofacial Surgery, Medical School, University of Ioannina, Ioannina, Greece., Mastronikolis N; Department of Otolaryngology, Medical School, University of Patras, Greece., Kyrodimos E; First Department of Otolaryngology, 'Hippocration' Hospital, Medical school, National and Kapodistrian University of Athens, Athens, Greece.
Jazyk: angličtina
Zdroj: Maedica [Maedica (Bucur)] 2024 Jun; Vol. 19 (2), pp. 355-359.
DOI: 10.26574/maedica.2024.19.2.355
Abstrakt: Introduction: Onset and progression of malignant tumors is a multistep process including a variety of gross chromosomal and specific genes' deregulation. Among oncogenes that are frequently altered in solid and also in hematological malignancies, the C-myc (gene locus: 8q24.21) plays a pivotal role. C-myc is a proto-oncogene encoding for a nuclear phosphoprotein implicated in cell cycle progression, apoptosis and cellular differentiation and transformation.
Objective: The purpose of the current molecular review was to explore the differences of C-myc oncogenic activity in solid and lymphoid malignancies that modify its clinical impact on them.
Material and Method: A systematic review of the literature in the international database PubMed was carried out. The year 2010 was set as a prominent time limit for the publication date of articles in the majority of them, whereas specific references of great importance and historical value in the field of C-myc gene discovery and analysis were also included. The following keywords were used: C-myc, oncogene, signaling pathway, malignancies, carcinoma, lymphoma. A pool of 43 important articles were selected for the present study at the basis of combining molecular knowledge with new targeted therapeutic strategies.
Results: C-myc oncogene demonstrates two different mechanisms of deregulation: amplification, mutation and translocation patterns. These particular aspects of gene alteration are unique for solid and non-solid (hematological) malignancies, respectively.
Conclusions: C-myc is characterized by diversity regarding its deregulation mechanisms in malignancies derived from different tissues. C-myc translocation is sporadically combined with amplification ("complicon" formation) or mutations creating exotic genetic signatures. This "bi-phasic" C-myc deregulation model in the corresponding malignant tumor categories clinically affects the corresponding patients, also modifying the targeted therapeutic strategies on them.
Databáze: MEDLINE
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