Very late relapse of Burkitt's lymphoma in an EBV-negative patient after 20 years of complete remission.

Autor:	Mrad K; Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia., Slama N; Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia., Ben Abdeljalil N; Pathology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia., Mlayah Z; Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia., Boufrikha W; Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia., Zakhama A; Pathology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia., Boukhris S; Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia., Laatiri MA; Hematology Department, Fattouma Bourguiba University Hospital of Monastir, Avenue Farhat Hached, Monastir, 5000, Tunisia.
Jazyk:	angličtina
Zdroj:	Leukemia research reports [Leuk Res Rep] 2024 Jul 29; Vol. 22, pp. 100470. Date of Electronic Publication: 2024 Jul 29 (Print Publication: 2024).
DOI:	10.1016/j.lrr.2024.100470
Abstrakt:	Burkitt's lymphoma (BL) is an aggressive B-cell lymphoma that occurs in children and adults. It is a chemosensitive lymphoma with very exceptional cases of late relapse. We report the case of a 32-year-old male, originally from a nonendemic area for BL, who was successfully treated for abdominal BL 20 years ago. He described a two-month history of cervical swelling and a one-week history of dyspnea. Physical examination was unremarkable except for a left submandibular mass that extended to the collarbone. An ultrasound of the neck revealed cervical lymphadenopathy. The patient was submitted to a lymph node biopsy with an immunohistochemical analysis, which concluded to the diagnosis of BL. Screening for recent Epstein-Barr-Virus (EBV) infection was negative. We considered this a very late relapse (VLR) of the original disease, and the patient was treated according to the same initial protocol. Unfortunately, he suffered a second relapse and died. We report an unusual case of a VLR of nonendemic BL in an EBV-negative patient, occurring 20 years after achieving complete remission following the initial chemotherapy. Competing Interests: The authors declare that they have no conflict of interest. (© 2024 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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