High-Density Lipoproteins-Cholesterol (HDL-C) in Women With Gestational Diabetes (GDM): A Predictor for Large Gestational Age (LGA) Babies.

Autor:	Pereira AP; Department of Medicine, Universidade Federal de São Paulo, São Paulo, BRA., Montero MF; Department of Endocrinology, Universidade Federal de São Paulo, São Paulo, BRA., Souza FD; Department of Endocrinology, Universidade Federal de São Paulo, São Paulo, BRA., Jordão MC; Department of Endocrinology, Universidade Federal de São Paulo, São Paulo, BRA., Oliveira MCM; Department of Endocrinology, Universidade Federal de São Paulo, São Paulo, BRA., Mattar R; Department of Obstetrics and Gynecology, Universidade Federal de São Paulo, São Paulo, BRA., Dib SA; Department of Endocrinology, Universidade Federal de São Paulo, São Paulo, BRA., Dualib PM; Department of Endocrinology, Universidade Federal de São Paulo, São Paulo, BRA., de Almeida-Pititto B; Department of Preventive Medicine, Universidade Federal de São Paulo, São Paulo, BRA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jul 27; Vol. 16 (7), pp. e65546. Date of Electronic Publication: 2024 Jul 27 (Print Publication: 2024).
DOI:	10.7759/cureus.65546
Abstrakt:	Introduction The present study aimed to evaluate the associations between the clinical and biochemical characteristics of women with gestational diabetes (GDM) and the incidence of large for gestational age (LGA) babies. Methods This cohort study included data collected during prenatal follow-up of GDM women from January 2008 to August 2022. Clinical and biochemical variables were compared among small (SGA), adequate (AGA), or large for gestational age (LGA) babies. Associations of the main variables with the incidence of LGA were determined by multiple regression analysis. Results Out of 659 women, 56 had LGA, 547 had AGA, and 56 had SGA babies. We observed differences in the means of age, pregestational body mass index (BMI), high-density lipoproteins-cholesterol (HDL-C) levels, gestational weight gain (GWG), and gestational age at birth according to LGA, AGA, and SGA (p < 0.05). All other variables were not different between the groups. The frequencies (%) and relative risk (RR) of LGA babies were evaluated according to HDL-C in the first tertile and/or obesity, with 12.2% and risk ratio (RR)=2.77 (95% confidence interval (CI) 1.35-5.69, p=0.005) if the women had obesity and HDL in the first tertile, 11.3% and RR=2.27 (95% CI 1.03-5.03, p=0.042) if only HDL in the first tertile was present, 10.9% and RR=2.68 (95% CI 1.31-5.48, p=0.007) if the women had only obesity, using as a reference group those women without obesity or HDL-C in the first tertile (4.6% and RR=1) adjusted for age, age at birth and GWG. Conclusion In women with GDM, lower levels of HDL-cholesterol during pregnancy, as well as pregestational obesity, seem to be good predictors of the occurrence of LGA babies. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Research Ethics Committee of the Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo (UNIFESP) issued approval 57520822.4.0000.5505. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Pereira et al.)
Databáze:	MEDLINE
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