Experimental Use of Common Marmosets (Callithrix jacchus) in Preclinical Trials of Antiviral Vaccines.

Autor:	Gordeychuk IV; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation.; Institute for Translational Medicine and Biotechnology, Sechenov University, Moscow, 117418 Russian Federation., Gancharova OS; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation.; Belozersky Institute of Physico-Chemical Biology, M.V. Lomonosov Moscow State University, Moscow, 119992 Russian Federation., Gulyaev SA; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Gulyaeva TV; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Zhitkevich AS; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Avdoshina DV; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Moroz AV; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Lunin AS; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Sotskova SE; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Korduban EA; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Tukhvatulin AI; National Research Centre for Epidemiology and Microbiology named after Honorary Academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, Moscow, 123098 Russin Federation., Bayurova EO; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation., Ishmukhametov AA; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow, 108819 Russian Federation.; Institute for Translational Medicine and Biotechnology, Sechenov University, Moscow, 117418 Russian Federation.
Jazyk:	angličtina
Zdroj:	Acta naturae [Acta Naturae] 2024 Apr-Jun; Vol. 16 (2), pp. 30-39.
DOI:	10.32607/actanaturae.27372
Abstrakt:	Common marmoset ( Callithrix jacchus , CM) is a New World primate species that is of interest for preclinical trials of immunobiological products. In this study, we describe the approaches to long-term laboratory breeding and maintenance of CMs. We also establish the reference values of the main complete blood count and serum chemistry parameters evaluated during preclinical trials of immunobiological products and describe the histological characteristics of CM lymphoid organs during the development of post-vaccination immune response. We show that CMs bred in laboratory conditions excluding background infectious pathology are a relevant model that allows for a high degree of reliability in characterizing the safety and immunogenicity profile of antiviral vaccines during preclinical trials. (Copyright ® 2024 National Research University Higher School of Economics.)
Databáze:	MEDLINE
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