Oral microbiome diversity and diet quality in relation to mortality.

Autor: Shen J; School of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Chen H; School of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhou X; State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China., Huang Q; State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China., Garay LG; School of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Zhao M; School of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Qian S; Department of Oral Implantology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center of Stomatology; National Clinical Research Center for Oral Diseases; Shanghai key Laboratory of Stomatology, Shanghai, China., Zong G; CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China., Yan Y; The Center for Microbes, Development and Health, CAS Key Laboratory of Molecular Virology and Immunology, Chinese Academy of Sciences, Shanghai, China., Wang X; State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China., Wang B; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China., Tonetti M; Department of Oral Implantology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center of Stomatology; National Clinical Research Center for Oral Diseases; Shanghai key Laboratory of Stomatology, Shanghai, China., Zheng Y; State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China., Yuan C; School of Public Health, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: Journal of clinical periodontology [J Clin Periodontol] 2024 Nov; Vol. 51 (11), pp. 1478-1489. Date of Electronic Publication: 2024 Aug 26.
DOI: 10.1111/jcpe.14050
Abstrakt: Aim: To examine the independent and joint associations of oral microbiome diversity and diet quality with risks of all-cause and cause-specific mortality.
Materials and Methods: We included 7,055 eligible adults from the U.S. National Health and Nutrition Examination Survey (NHANES). Oral microbiome diversity was measured with α-diversity, including the Simpson Index, observed amplicon sequence variants (ASVs), Faith's phylogenetic diversity, and Shannon-Weiner index. Dietary quality was assessed using the Healthy Eating Index-2015 (HEI-2015). Cox proportional hazard models were used to assess the corresponding associations.
Results: During a mean follow-up of 9.0 years, we documented 382 all-cause deaths. We observed independent associations of oral microbiome diversity indices and dietary quality with all-cause mortality (hazard ratio [HR] = 0.63; 95% confidence interval [CI]: 0.49-0.82 for observed ASVs; HR = 0.68, 95% CI: 0.52-0.89 for HEI-2015). Jointly, participants with the highest tertiles of both oral microbiome diversity (in Simpson index) and HEI-2015 had the lowest hazard of mortality (HR = 0.37, 95% CI: 0.23-0.60). In addition, higher oral microbiome diversity was associated with lower risks of deaths from cardiometabolic disease and cancer.
Conclusions: Higher oral microbiome α-diversity and diet quality were independently associated with lower risk of mortality.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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