Phenotypic switch of vascular smooth muscle cells in COVID-19: Role of cholesterol, calcium, and phosphate.

Autor: Ghanem L; Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon., Essayli D; Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon., Kotaich J; Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon.; MEDICA Research Investigation, Beirut, Lebanon., Zein MA; Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon., Sahebkar A; Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran., Eid AH; Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Jazyk: angličtina
Zdroj: Journal of cellular physiology [J Cell Physiol] 2024 Dec; Vol. 239 (12), pp. e31424. Date of Electronic Publication: 2024 Aug 26.
DOI: 10.1002/jcp.31424
Abstrakt: Although the novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), primarily manifests as severe respiratory distress, its impact on the cardiovascular system is also notable. Studies reveal that COVID-19 patients often suffer from certain vascular diseases, partly attributed to increased proliferation or altered phenotype of vascular smooth muscle cells (VSMCs). Although the association between COVID-19 and VSMCs is recognized, the precise mechanism underlying SARS-CoV-2's influence on VSMC phenotype remains largely under-reviewed. In this context, while there is a consistent body of literature dissecting the effect of COVID-19 on the cardiovascular system, few reports delve into the potential role of VSMC switching in the pathophysiology associated with COVID-19 and the molecular mechanisms involved therein. This review dissects and critiques the link between COVID-19 and VSMCs, with particular attention to pathways involving cholesterol, calcium, and phosphate. These pathways underpin the interaction between the virus and VSMCs. Such interaction promotes VSMC proliferation, and eventually potentiates vascular calcification as well as worsens prognosis in patients with COVID-19.
(© 2024 The Author(s). Journal of Cellular Physiology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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