Challenges and future directions of SUDEP models.

Autor: Gu J; Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China., Shao W; Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China., Liu L; Department of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China., Wang Y; Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China., Yang Y; Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China., Zhang Z; Department of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China., Wu Y; Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China., Xu Q; Department of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China., Gu L; Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China., Zhang Y; Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China., Shen Y; Department of Anesthesiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, China., Zhao H; Department of Neurology, Xiangya Hospital, Central South University, Changsha, China., Zeng C; Health Management Center, Xiangya Hospital, Central South University, Changsha, China., Zhang H; Department of Anesthesiology, the Fourth Clinical School of Medicine, Zhejiang Chinese Medical University, Hangzhou, China. zhh0902@zju.edu.cn.; Department of Anesthesiology, Zhejiang University School of Medicine, Hangzhou, China. zhh0902@zju.edu.cn.; Department of Anesthesiology, Affiliated Hangzhou First People's Hospital, Westlake University School of Medicine, Hangzhou, China. zhh0902@zju.edu.cn.
Jazyk: angličtina
Zdroj: Lab animal [Lab Anim (NY)] 2024 Sep; Vol. 53 (9), pp. 226-243. Date of Electronic Publication: 2024 Aug 26.
DOI: 10.1038/s41684-024-01426-y
Abstrakt: Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death among patients with epilepsy, causing a global public health burden. The underlying mechanisms of SUDEP remain elusive, and effective prevention or treatment strategies require further investigation. A major challenge in current SUDEP research is the lack of an ideal model that maximally mimics the human condition. Animal models are important for revealing the potential pathogenesis of SUDEP and preventing its occurrence; however, they have potential limitations due to species differences that prevent them from precisely replicating the intricate physiological and pathological processes of human disease. This Review provides a comprehensive overview of several available SUDEP animal models, highlighting their pros and cons. More importantly, we further propose the establishment of an ideal model based on brain-computer interfaces and artificial intelligence, hoping to offer new insights into potential advancements in SUDEP research. In doing so, we hope to provide valuable information for SUDEP researchers, offer new insights into the pathogenesis of SUDEP and open new avenues for the development of strategies to prevent SUDEP.
(© 2024. Springer Nature America, Inc.)
Databáze: MEDLINE
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