Intracellular Trafficking Defects in Congenital Intestinal and Hepatic Diseases.

Autor: Szabó L; Institute of Cell Biology, Medical University of Innsbruck, Innsbruck, Austria., Pollio AR; Institute of Cell Biology, Medical University of Innsbruck, Innsbruck, Austria., Vogel GF; Institute of Cell Biology, Medical University of Innsbruck, Innsbruck, Austria.; Department of Paediatrics I, Medical University of Innsbruck, Innsbruck, Austria.
Jazyk: angličtina
Zdroj: Traffic (Copenhagen, Denmark) [Traffic] 2024 Aug; Vol. 25 (8), pp. e12954.
DOI: 10.1111/tra.12954
Abstrakt: Enterocytes and liver cells fulfill important metabolic and barrier functions and are responsible for crucial vectorial secretive and absorptive processes. To date, genetic diseases affecting metabolic enzymes or transmembrane transporters in the intestine and the liver are better comprehended than mutations affecting intracellular trafficking. In this review, we explore the emerging knowledge on intracellular trafficking defects and their clinical manifestations in both the intestine and the liver. We provide a detailed overview including more investigated diseases such as the canonical, variant and associated forms of microvillus inclusion disease, as well as recently described pathologies, highlighting the complexity and disease relevance of several trafficking pathways. We give examples of how intracellular trafficking hubs, such as the apical recycling endosome system, the trans-Golgi network, lysosomes, or the Golgi-to-endoplasmic reticulum transport are involved in the pathomechanism and lead to disease. Ultimately, understanding these processes could spark novel therapeutic approaches, which would greatly improve the quality of life of the affected patients.
(© 2024 The Author(s). Traffic published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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