Analysis of Single Nucleotide Polymorphisms (SNPs) rs2234693 and rs9340799 of the ESR1 Gene and the Risk of Breast Cancer.

Autor:	Smolarz B; Laboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland; smolbea@wp.pl., Nowak AZ; Department of Chemotherapy, Medical University of Lodz, Copernicus Memorial Hospital, Lodz, Poland., Bryś M; Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland., Forma E; Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland., Łukasiewicz H; Department of Obstetrics and Gynecology and Gynecological Oncology, Regional Hospital in Kalisz, Kalisz, Poland., Samulak D; Department of Obstetrics and Gynecology and Gynecological Oncology, Regional Hospital in Kalisz, Kalisz, Poland.; Department of Obstetrics, The President Stanisław Wojciechowski Calisia Academyin, Kalisz, Poland., Langner S; Medical University of Gdańsk, Gdańsk, Poland., Romanowicz H; Laboratory of Cancer Genetics, Department of Pathology, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
Jazyk:	angličtina
Zdroj:	In vivo (Athens, Greece) [In Vivo] 2024 Sep-Oct; Vol. 38 (5), pp. 2134-2143.
DOI:	10.21873/invivo.13676
Abstrakt:	Background/aim: The aim of this study was to analyze rs2234693 and rs9340799 polymorphisms of the ESR1 gene in the context of breast cancer risk in Polish patients. Materials and Methods: The study involved a group of 117 patients with breast cancer and 106 controls. The analyses were carried out using the polymerase chain reaction - restriction fragments length polymorphism technique. Results: The presence of the CC genotype in rs2234693 more than doubled the risk of breast cancer (p=0.04), whereas the presence of the TT genotype in rs2234693 significantly reduced the risk of developing this type of cancer (p=0.0002). The presence of the GG genotype in rs9340799 more than doubled the risk of breast cancer (p=0.04), which was confirmed by the analysis of the recessive model (p=0.04). Conclusion: The polymorphisms rs2234693 and rs9340799 of the ESR1 gene may be associated with the risk of breast cancer among Polish women. (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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