A Rapidly Developing Nodule in a Patient With Hairy Cell Leukemia in Remission: Merkel Cell Carcinoma: A Case Report.

Autor:	Sachanas S; Department of Hematology, Athens Medical Center-Psychikon Branch, Athens, Greece; ssachanas@gmail.com., Stefanaki C; Athens Medical Center-Psychikon Branch, Athens, Greece., Marinos L; Department of Hematopathology, Evangelismos General Hospital, Athens, Greece., Yiakoumis X; Department of Hematology, Athens Medical Center-Psychikon Branch, Athens, Greece., Moschogiannis M; Department of Hematology, Athens Medical Center-Psychikon Branch, Athens, Greece., Koulieris E; Department of Hematology, Athens Medical Center-Psychikon Branch, Athens, Greece., Efstathopoulou M; Department of Hematology, Athens Medical Center-Psychikon Branch, Athens, Greece., Pangalis GA; Department of Hematology, Athens Medical Center-Psychikon Branch, Athens, Greece.
Jazyk:	angličtina
Zdroj:	In vivo (Athens, Greece) [In Vivo] 2024 Sep-Oct; Vol. 38 (5), pp. 2540-2544.
DOI:	10.21873/invivo.13727
Abstrakt:	Background/aim: Hairy cell leukemia (HCL) is a well-known lymphoproliferative disease with very effective treatment approaches primarily relying on purine analogues. However, these treatments are associated with profound and prolonged immunosuppression. Merkel cell carcinoma (MCC) is a rare and extremely aggressive skin tumor with an increased incidence in immunocompromised patients. Case Report: We report a case of a patient with HCL who was diagnosed with MCC, while in remission following retreatment with pentostatin, which induced a profound decrease in CD4 (+) T-cells. Conclusion: Our case provides further evidence supporting the hypothesis of a significant association between immunosuppression and MCC pathogenesis. (Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
Databáze:	MEDLINE
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