Drug Allergies in Older Adults: A Major Problem in a Specific Population.

Autor:	Kılınç M; Division of Clinical Immunology and Allergy, Batman Training and Research Hospital, Batman, Turkey., Çölkesen F; Department of Internal Medicine, Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey., Sadi Aykan F; Division of Clinical Immunology and Allergy, Gulhane Training and Research Hospital, Ankara, Turkey., Evcen R; Division of Clinical Immunology and Allergy, Rize Training and Research Hospital, Rize, Turkey., Yıldız E; Division of Clinical Immunology and Allergy, Necip Fazıl City Hospital, Kahramanmaraş, Turkey., Önalan T; Department of Internal Medicine, Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey., Yılmaz Ergün Ü; Department of Internal Medicine, Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey., Akkuş FA; Department of Internal Medicine, Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey., Gerek ME; Department of Internal Medicine, Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey., Kahraman S; Department of Internal Medicine, Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey., Arslan Ş; Department of Internal Medicine, Division of Clinical Immunology and Allergy, Necmettin Erbakan University, Faculty of Medicine, Konya, Turkey.
Jazyk:	angličtina
Zdroj:	International archives of allergy and immunology [Int Arch Allergy Immunol] 2024 Aug 26, pp. 1-8. Date of Electronic Publication: 2024 Aug 26.
DOI:	10.1159/000540374
Abstrakt:	Introduction: The use of medications in older adults is increasing due to the prevalence of chronic diseases. Data on the characteristics of drug allergies (DAs) in older adults are limited. This study investigated the prevalence and clinical characteristics of DAs in patients aged 65 years and older. Methods: Patient records were examined retrospectively between January 2018 and December 2022. The study included 200 patients aged ≥18 years who met the criteria for diagnosis of type B drug reactions. The patients were divided into two groups: the adult group (18-64 years) and the older adult group (≥65 years). Results: Advanced age was an independent risk factor for the development of anaphylaxis and immediate and delayed hypersensitivity reactions (odds ratio [OR] = 4.296; 95% confidence interval [CI] = 1.700-10.855; p = 0.002, OR = 3.800; 95% CI = 1.247-11.579; p = 0.019, OR = 3.028; 95% CI = 1.248-7.343; p = 0.014, respectively). Older adults had higher rates of comorbidities and polypharmacy (p < 0.001, p = 0.016, respectively), beta-lactam antibiotic allergy (p < 0.001), and hospitalization and intensive care unit (ICU) admission for DAs (p = 0.024, p = 0.045, respectively). Conclusion: Older age was an independent risk factor for anaphylaxis and both immediate and delayed reactions. Older adults had higher rates of comorbidities, polypharmacy, beta-lactam antibiotic triggers, and hospitalization and ICU admission. (© 2024 S. Karger AG, Basel.)
Databáze:	MEDLINE
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