Zinc and thyroid cancer: A systematic review and meta-analysis protocol.

Autor: Soares AA; Postgraduating Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Department of Nutrition, Liga Contra o Câncer, Natal, RN, Brazil., Nagashima YG; Postgraduating Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Department of Nutrition, Liga Contra o Câncer, Natal, RN, Brazil., Alves CX; Department of Nutrition, Liga Contra o Câncer, Natal, RN, Brazil., de Medeiros KS; Pesquisa e Inovação, Liga Contra o Câncer, Instituto de Ensino, Natal, RN, Brazil., Lopes MMGD; Department of Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.; Department of Nutrition.Federal University of Rio Grande do Norte, Natal, RN, Brazil., Brandão-Neto J; Department of Internal Medicine, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Aug 26; Vol. 19 (8), pp. e0307617. Date of Electronic Publication: 2024 Aug 26 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0307617
Abstrakt: Introduction: The thyroid cancer has the ninth larger incidence of cancer in the world. Investigations related to the exposure to metals have become important due to the sensibility of the thyroid gland to them. Studies reveal that carcinogenic progressions are associated to the deficiency of the essential trace elements. In this context, the zinc is highlighted, essential for the metabolism of the thyroidal hormone and has a potential relation with the pathogenesis of the thyroid cancer. The objective of this systematic review and meta-analysis is to evaluate the low serum zinc as a risk factor for thyroid cancer in adults.
Methods and Analysis: PubMed/MEDLINE, Scopus, Embase and LILACS databases will be searched for observational studies investigating the low serum zinc as a risk factor for thyroid cancer in adults. No language or publication period restrictions will be imposed. The primary outcome will be that the low serum zinc is a risk factor for thyroid cancer. Three independent reviewers will select the studies and extract data from the original publications. The risk-of-bias will be assessed by using the Newcastle-Ottawa Quality Assessment Scale (NOS). Data synthesis will be performed using the R software (V.4.3.1) and to assess heterogeneity, we will compute the I2 statistic and the results will be based on either random-effects or fixed-effects models, depending on the heterogeneity. The Grading of Recommendations, Development, and Evaluation (GRADE) system will be used to evaluate the reliability and quality of evidence.
Prospero Registration Number: International Prospective Register of Systematic Reviews (PROSPERO) CRD42023463747.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Soares et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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