Exploring gastrointestinal manifestations in childhood onset systemic lupus erythematosus - Insights from a multicenter study.

Autor: Sönmez HE; Faculty of Medicine, Department of Pediatric Rheumatology, Kocaeli University, Kocaeli, Turkey., Batu ED; Faculty of Medicine, Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey., İşgüder R; Faculty of Medicine, Department of Pediatric Rheumatology, Dokuz Eylül University, Izmir, Turkey., Şahin N; Faculty of Medicine, Department of Pediatric Rheumatology, Kocaeli University, Kocaeli, Turkey., Aliyev E; Faculty of Medicine, Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey., Aslan E; Cerrahpaşa Medical Faculty, Department of Pediatric Rheumatology, Istanbul University-Cerrahpaşa, Istanbul, Turkey., Çoban S; Department of Pediatric Rheumatology, Umraniye Training and Research Hospital, Istanbul, Turkey., Güngörer V; Department of Pediatric Rheumatology, Ankara Bilkent City Hospital, Ankara, Turkey., Karadağ ŞG; Faculty of Medicine, Department of Pediatric Rheumatology, Istanbul University, Istanbul, Turkey., Karaçayır N; Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey., Kısaoğlu H; Department of Pediatric Rheumatology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey., Yekedüz Bülbül A; Department of Pediatric Rheumatology, Erciyes University, Kayseri, Turkey., Garip S; Department of Pediatric Gastroenterology, Adana City Training and Research Hospital, Adana, Turkey., Karalı Y; Department of Pediatric Rheumatology, Uludağ University, Bursa, Turkey., Ayduran S; Department of Pediatric Rheumatology, Pamukkale University, Denizli, Turkey., Demir S; Department of Pediatric Rheumatology, Osmangazi University, Eskişehir, Turkey., Kaya Akça Ü; Department of Pediatric Rheumatology, Aydın State Hospital, Aydın, Turkey., Başaran Ö; Faculty of Medicine, Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey., Şahin S; Cerrahpaşa Medical Faculty, Department of Pediatric Rheumatology, Istanbul University-Cerrahpaşa, Istanbul, Turkey., Kasap B; Department of Pediatric Rheumatology, Izmir Katip Celebi University, Izmir, Turkey., Kilic SS; Department of Pediatric Rheumatology, Uludağ University, Bursa, Turkey., Kışla Ekinci RM; Department of Pediatric Gastroenterology, Adana City Training and Research Hospital, Adana, Turkey., Kısaarslan AP; Department of Pediatric Rheumatology, Erciyes University, Kayseri, Turkey., Kalyoncu M; Department of Pediatric Rheumatology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey., Bakkaloğlu S; Department of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey., Yüksel S; Department of Pediatric Rheumatology, Çanakkale Onsekiz Mart University, Çanakkale, Turkey., Aktay Ayaz N; Faculty of Medicine, Department of Pediatric Rheumatology, Istanbul University, Istanbul, Turkey., Çelikel Acar B; Department of Pediatric Rheumatology, Ankara Bilkent City Hospital, Ankara, Turkey., Sözeri B; Department of Pediatric Rheumatology, Umraniye Training and Research Hospital, Istanbul, Turkey., Kasapçopur Ö; Cerrahpaşa Medical Faculty, Department of Pediatric Rheumatology, Istanbul University-Cerrahpaşa, Istanbul, Turkey., Ünsal E; Faculty of Medicine, Department of Pediatric Rheumatology, Dokuz Eylül University, Izmir, Turkey., Özen S; Faculty of Medicine, Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey.
Jazyk: angličtina
Zdroj: Lupus [Lupus] 2024 Aug 26, pp. 9612033241279071. Date of Electronic Publication: 2024 Aug 26.
DOI: 10.1177/09612033241279071
Abstrakt: Objective: Systemic lupus erythematosus (SLE) constitutes an autoimmune disorder with potential involvement of the gastrointestinal system (GIS). Our objective was to assess the gastrointestinal (GI) manifestations in patients diagnosed with childhood onset SLE.
Methods: The study cohort consisted of 123 patients with childhood onset-SLE and GIS involvement from 16 referral departments of pediatric rheumatology. All participants met the Systemic Lupus International Collaborating Clinics criteria.
Results: Out of 123 patients, 78 (63.4%) exhibited GIS involvement at the initial SLE diagnosis, whereas the remaining 45 (36.6%) developed GI symptoms after a median duration of 12 (3-140) months. Eighty-two (66.7%) individuals experienced symptoms related to the GI tract, whereas the remaining patients received a diagnosis of GI involvement through laboratory assessments. The predominant initial GIS involvement symptom was abdominal pain, observed in 77 (62.6%) patients, followed by elevated hepatic transaminases in 70 (56.9%), hepatomegaly in 40 (32.5%), diarrhea in 26 (21.1%), and jaundice in 11 (8.9%) patients. The GIS involvement was associated with SLE in 82 (78.6%), while it resulted from drug-related adverse events in 35 (28.5%) patients or comorbidities in 6 (0.5%) patients.
Conclusion: GIS involvement should be considered in all childhood onset-SLE patients, especially in the presence of suggestive symptoms or elevated hepatic transaminases. It is also crucial to consider SLE in the differential diagnosis of GIS manifestations in children. Apart from GIS involvement directly associated with SLE, adverse events of drugs should be kept in mind.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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