Potential for reducing dementia risk: association of the CAIDE score with additional lifestyle components from the LIBRA score in a population at high risk of dementia.
| Autor: | Claus M; Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany., Luppa M; Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany., Zülke A; Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany., Blotenberg I; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany., Cardona MI; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany., Döhring J; Institute of General Practice, University of Kiel, Kiel, Germany., Escales C; Institute of General Practice, University of Kiel, Kiel, Germany., Kosilek RP; Institute of General Practice and Family Medicine, University Hospital of LMU Munich, Munich, Germany., Oey A; Institute for General Practice, Work Group Medical Statistics and IT-Infrastructure, Hannover Medical School, Hannover, Germany., Zöllinger I; Institute of General Practice and Family Medicine, University Hospital of LMU Munich, Munich, Germany., Brettschneider C; Department of Health Economics and Health Service Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Czock D; Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany., Frese T; Institute of General Practice and Family Medicine, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany., Gensichen J; Institute of General Practice and Family Medicine, University Hospital of LMU Munich, Munich, Germany., Hoffmann W; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald (UMG), Greifswald, Germany., Kaduszkiewicz H; Institute of General Practice, University of Kiel, Kiel, Germany., König HH; Department of Health Economics and Health Service Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Wiese B; Institute for General Practice, Work Group Medical Statistics and IT-Infrastructure, Hannover Medical School, Hannover, Germany., Thyrian JR; German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany., Riedel-Heller SG; Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany. |
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| Jazyk: | angličtina |
| Zdroj: | Aging & mental health [Aging Ment Health] 2024 Aug 26, pp. 1-8. Date of Electronic Publication: 2024 Aug 26. |
| DOI: | 10.1080/13607863.2024.2394591 |
| Abstrakt: | Objectives: Various dementia risk scores exist that assess different factors. We investigated the association between the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) score and modifiable risk factors in the Lifestyle for Brain Health (LIBRA) score in a German population at high risk of Alzheimer's disease. Method: Baseline data of 807 participants of AgeWell.de (mean age: 68.8 years (SD = 4.9)) were analysed. Stepwise multivariable regression was used to examine the association between the CAIDE score and additional risk factors of the LIBRA score. Additionally, we examined the association between dementia risk models and cognitive performance, as measured by the Montreal Cognitive Assessment. Results: High cognitive activity (β = -0.016, p < 0.001) and high fruit and vegetable intake (β = -0.032, p < 0.001) correlated with lower CAIDE scores, while diabetes was associated with higher CAIDE scores (β = 0.191; p = 0.032). Although all were classified as high risk on CAIDE, 31.5% scored ≤0 points on LIBRA, indicating a lower risk of dementia. Higher CAIDE and LIBRA scores were associated with lower cognitive performance. Conclusion: Regular cognitive activities and increased fruit and vegetable intake were associated with lower CAIDE scores. Different participants are classified as being at-risk based on the dementia risk score used. |
| Databáze: | MEDLINE |
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