Phyllanretiosides A and B: Two Undescribed Compounds from Phyllanthus reticulatus with Nitric Oxide Production Inhibition and Antimicrobial Activity.

Autor: Hai Yen DT; Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, Hanoi, VIET NAM., Huu Tai B; Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM., Yen PH; Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM., Hoang NH; Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, 10072, Hanoi, VIET NAM., Huong PTTTT; Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Hanoi, Hanoi, 10072, Hanoi, VIET NAM., Bang NA; Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, Hoang Quoc Viet, Hanoi, Hanoi, VIET NAM., Dung DT; Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18 Hoang Quoc Viet, Cau Giay,, Hanoi, Hanoi, VIET NAM., Trang DT; Vietnam Academy of Science and Technology, Institute of Marine Biochemistry, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam, Hanoi, 10072, Hanoi, VIET NAM., Anh LT; Vietnam Academy of Science and Technology, Vietnam National Museum of Nature, 18 Hoang Quoc Viet, Cau Giay,, Hanoi, 10072, Hanoi, VIET NAM., Kiem PV; Vietnam Academy of Science and Technology, Department of Structural Research, 18 Hoang Quoc Viet, 10000, Hanoi, VIET NAM.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Aug 26, pp. e202401608. Date of Electronic Publication: 2024 Aug 26.
DOI: 10.1002/cbdv.202401608
Abstrakt: Phytochemical study on the methanol extract of the leaves of Phyllanthus reticulatus led to the isolation of two new compounds, phyllanreticosides A (1) and B (2) together with ten known ones (3-12). Their chemical structures were determined by HR-ESI-MS, NMR, and ECD spectra in comparison with the literature. Three ellagitannins, phyllanreticoside A (1), corilagin (3), and phyllanthusiin C (4) inhibited lipopolysaccharide(LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values of 63.2, 83.2, and 5.6 µM, respectively. In addition, compounds 1, 3, and 4 exhibited significantly antimicrobial activity (MICs: 16-128 µg/mL) towards some of seven microbial strains, including Bacillus cereus, Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, and Candida albicans.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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