High rates of anal Merkel Cell Polyomavirus and HPV co-infection among people living with HIV.

Autor: Passerini S; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., Fracella M; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy., Benvenuto D; Dipartimento di Sicurezza e Bioetica, Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy., Bugani G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., D'Auria A; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy., Coratti E; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy., Babini G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., Moens U; Department of Medical Biology, Faculty of Health Sciences, University of Tromsø-The Arctic University of Norway, Tromsø, Norway., Cavallari EN; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., Torti C; Dipartimento di Sicurezza e Bioetica, Sezione di Malattie Infettive, Università Cattolica del Sacro Cuore, Rome, Italy.; Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy., Antonelli G; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy., Ciccozzi M; Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy., Pierangeli A; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy., d'Ettorre G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy., Scagnolari C; Department of Molecular Medicine, Laboratory of Virology, Sapienza University of Rome, Rome, Italy., Pietropaolo V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2024 Aug; Vol. 96 (8), pp. e29883.
DOI: 10.1002/jmv.29883
Abstrakt: Knowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes. HPV DNA was found in 50.7% of cases, with a predominance of high-risk (HR) genotypes. HPyV DNA was found in 39.3% of samples, with Merkel Cell Polyomavirus (MCPyV) being the most common, with a higher viral load than JCPyV and BKPyV. In addition, MCPyV viral load increased in people living with HIV (PLWH) with HPV infection (p < 0.0001).
(© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
Externí odkaz: