Steatosis, inflammation, fibroprogression, and cirrhosis in remnant liver post-liver donation.

Autor: Jacob J; Department of Liver & Digestive Care Apollo Adlux Hospital Ernakulam Kerala India., Joseph A; Department of Gastroenterology and Hepatology Ernakulam Medical Centre Kochi Kerala India., Nair HR; Department of Gastroenterology and Hepatology Ernakulam Medical Centre Kochi Kerala India., Prasad GP; Department of Liver & Digestive Care Apollo Adlux Hospital Ernakulam Kerala India., Kumar VV; Department of Liver & Digestive Care Apollo Adlux Hospital Ernakulam Kerala India., Padmakumari LT; Department of Radiology Apollo Adlux Hospital Ernakulam Kerala India.
Jazyk: angličtina
Zdroj: JGH open : an open access journal of gastroenterology and hepatology [JGH Open] 2024 Aug 23; Vol. 8 (8), pp. e70015. Date of Electronic Publication: 2024 Aug 23 (Print Publication: 2024).
DOI: 10.1002/jgh3.70015
Abstrakt: Background and Aim: This is a cross-sectional observational study conducted on living liver donors focusing on "long-term remnant liver health" specifically looking at steatosis, inflammation, and fibrosis using multiparametric ultra sonological evaluation and noninvasive blood tests.
Methods: Multiparametric ultrasound evaluation included assessment of shear wave elastography (fibrosis), sound speed plane wave ultrasound, attenuation plane wave ultrasound (steatosis), and viscosity plane wave ultrasound (inflammation). Blood test based APRI and FIB-4 were calculated. Liver biopsy was performed if noninvasive evaluation pointed toward clinically relevant fibro progression (F4).
Results: Out of 36 donors, significant fibrosis (>F2) was found in 11 donors (30.5%), seven donors (19.4%) had severe fibrosis (>F3), and two donors had shear wave elastography values suggestive of cirrhosis(F4). Of these two, one donor was extensively evaluated and was found to have biopsy proven cirrhosis with endoscopic evidence of portal hypertension. The prevalence of fatty liver disease in our study group was 50%.
Conclusion: We report the first liver donor cohort with fibroprogression and cirrhosis occurring in the remnant liver. Our donor cohort with a significant proportion having steatosis and fibroprogression underscores the importance of regular follow-up of liver donors and evaluation of remnant liver.
(© 2024 The Author(s). JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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