The Pathological Pattern of Breast Cancer in the Najran Region of Saudi Arabia: A Retrospective Study.

Autor: Alamri AM; Surgery, College of Medicine, Najran University, Najran, SAU., AlWadai HH; Surgery, College of Medicine, Najran University, Najran, SAU., Almowallad SM; Surgery, King Khalid Hospital, Najran, SAU., AlKulayb SM; Internal Medicine, Najran University, Najran, SAU., Abdalwahab ZE; Emergency Medicine, Najran University, Najran, SAU., Alzahuf SM; College of Medicine, Najran University, Najran, SAU., Alshaiban SH; College of Medicine, Najran University, Najran, SAU.
Jazyk: angličtina
Zdroj: Cureus [Cureus] 2024 Aug 23; Vol. 16 (8), pp. e67621. Date of Electronic Publication: 2024 Aug 23 (Print Publication: 2024).
DOI: 10.7759/cureus.67621
Abstrakt: Background Breast cancer (BC) is the most widespread cancer on a global scale, and its prevalence is likewise significant in the Kingdom of Saudi Arabia. Nevertheless, the data accessible regarding the epidemiology and histopathological characteristics of BC in clinical practice is restricted and primarily confined to research endeavors. Aim This study aims to investigate the histopathological profile of women diagnosed with BC seeking treatment at King Khalid Hospital in the Najran region of the Kingdom of Saudi Arabia. Methods In this retrospective study, BC biopsies performed on Saudi patients at King Khalid Hospital between January 2018 and December 2022 were examined. All records of breast biopsies from this timeframe were extracted from the hospital's histopathology laboratory computer database after written permission from the head of the laboratory department. For all neoplastic lesions, the World Health Organization's 2012 categorization of breast tumors was applied. Results A total of 61 women with BC were included. Women's age ranged from 30 to 89 years, with a mean age of 49.6 ± 12.3 years. The most reported BC was invasive ductal carcinoma (IDC; 70.5%). Other types reported included invasive papillary carcinoma (8.2%), ductal carcinoma in situ (4.9%), and invasive lobular carcinoma (3.3%). A total of 14 (23%) of the study women had multifocal cancer. Ki-67 was high in 19 cases (31.1%); six (9.8%) had BRCA1 mutations, and six (9.8%) had BRCA2 mutations. Conclusion The current study revealed that BC was frequent among young females, mainly IDC, which was reported on both sides at different sizes and grades. Breast lump was the most commonly presented symptom and had a high representation in women with hormonal receptors, mainly estrogen receptors, but positive genetic testing was infrequent.
Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. King Khalid Hospital Institution Review Board issued approval H-11-N-136. The protocol has been approved by the Institution Review Board (IRB) of King Khalid Hospital. The IRB has reviewed the research proposal and has determined that it meets the ethical standards outlined in the Belmont Report and the GCP ICH guidelines. Approval is given for one year from the date of this letter. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
(Copyright © 2024, Alamri et al.)
Databáze: MEDLINE