An Interprofessional Team for Disease-Modifying Therapy in Alzheimer Disease Implementation.

Autor:	Turk KW; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Knobel MD; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Nothern A; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Friedman G; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Noah H; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Campbell B; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Anderson DC; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Charidimou A; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Mills A; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Coronel V; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Pierre N; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Reynolds BV; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Wagner C; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Varga LM; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Roefaro J; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Triantafylidis L; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA., Budson AE; Neurology Service (KWT, MDK, GF, HN, BC, DCA, AC, BVR, AEB); Center for Translational Cognitive Neuroscience (KWT, MDK, GF, HN, BC, DCA, AC, AEB), VA Boston Healthcare System; Neurology Service (KWT, AEB), Alzheimer's Disease Research Center, Boston University School of Medicine; Geriatrics Service (AN); Radiology Service (AM); Nursing Service (VC, NP); and Clinical Pharmacy Service (CW, LMV, JR, LT), VA Boston Healthcare System, Boston, MA.
Jazyk:	angličtina
Zdroj:	Neurology. Clinical practice [Neurol Clin Pract] 2024 Dec; Vol. 14 (6), pp. e200346. Date of Electronic Publication: 2024 Aug 16.
DOI:	10.1212/CPJ.0000000000200346
Abstrakt:	Background: Lecanemab and other new amyloid-targeting immunotherapies for Alzheimer disease show notable promise but may also pose significant risk for patients. Recent Findings: To facilitate the implementation and monitoring of lecanemab infusions at our tertiary medical center, we convened an interprofessional team. The team created a number of resources including patient handouts and medical documentation templates as well as systems and processes that are likely to be useful to other clinical care settings and centers. Implications for Practice: It is our intent to widely share the resources and processes developed. Competing Interests: K.W. Turk reports research funding from the Alzheimer's association, US Department of Veterans Affairs, the Doris Duke Foundation and Vox Neuro incorporated. A.E. Budson reports Eli Lilly: Consultant, VoxNeuro: investigator initiated grant, Bristol Myers Squbb: investigator initiated grant, Oxford University Press: author royalties. Elsevier: author royalties. The other authors report no disclosures relevant to the manuscript. Full disclosure form information provided by the authors is available with the full text of this article at Neurology.org/cp.TAKE-HOME POINTS→ An interdisciplinary team was assembled to facilitate the initial rollout of disease modifying therapies for AD.→ The team developed patient-facing and internal documents to streamline initial medication roll out effectively.→ The team also developed policies, procedures, and weekly review processes for initial eligibility screening.→ The team has developed processes for ongoing imaging and clinical review of patients receiving infusions.→ Processes and resources developed are being disseminated for use and adaptation by others. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)
Databáze:	MEDLINE
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