An RNAi screen for ribosome biogenesis genes required for Drosophila border cell collective migration.
| Autor: | Burghardt E; Division of Biology, Kansas State University, Manhattan, Kansas, United States., McDonald JA; Division of Biology, Kansas State University, Manhattan, Kansas, United States. |
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| Jazyk: | angličtina |
| Zdroj: | MicroPublication biology [MicroPubl Biol] 2024 Aug 10; Vol. 2024. Date of Electronic Publication: 2024 Aug 10 (Print Publication: 2024). |
| DOI: | 10.17912/micropub.biology.001292 |
| Abstrakt: | Ribosome biogenesis is critical for the proper production of proteins in cells and has emerged as a regulator of cell invasion and migration in development and in cancer. The Drosophila border cells form a collective that invades and migrates through the surrounding tissue during oogenesis. We previously found that a significant number of ribosome biogenesis genes are differentially expressed from early to late migration stages. Here, we performed a small-scale RNAi screen of a subset of these ribosome genes. Knockdown of seven genes disrupted border cell migration, thus revealing a role for ribosome biogenesis genes in regulating collective cell migration. Competing Interests: The authors declare that there are no conflicts of interest present. (Copyright: © 2024 by the authors.) |
| Databáze: | MEDLINE |
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